Hammarström L, Granström M, Möllby R, Oxelius V, Persson M A, Smith C I
Acta Paediatr Scand. 1985 Jan;74(1):126-30. doi: 10.1111/j.1651-2227.1985.tb10933.x.
Anti-teichoic acid antibodies of various subclasses were found to be effectively transported across the placenta during pregnancy. In adults these antibodies are mainly of the IgG2 subclass although substantial amounts of specific IgG1 antibodies may also be found. During ontogeny, specific IgG1 antibodies develop during the second year of life whereas specific IgG2 antibodies appear markedly later. In IgG2 deficient children, prolonged deficiency of specific anti-teichoic acid antibodies was observed, suggesting a lack of maturation of the appropriate idiotype(s). In children who received a bone marrow transplant from adult donors, engraftment of IgG2 producing cells could be seen, thus transferring the ability to produce specific antibodies.
在孕期发现各种亚类的抗磷壁酸抗体可有效通过胎盘转运。在成年人中，这些抗体主要为IgG2亚类，不过也可能发现大量特异性IgG1抗体。在个体发育过程中，特异性IgG1抗体在生命的第二年产生，而特异性IgG2抗体出现的时间则明显更晚。在IgG2缺陷儿童中，观察到特异性抗磷壁酸抗体长期缺乏，提示缺乏合适独特型的成熟。在接受成年供体骨髓移植的儿童中，可以看到产生IgG2的细胞植入，从而转移了产生特异性抗体的能力。
