Mehrab Mohseni Mahdieh, Zamani Hedyeh, Momeni Mina, Shirvani-Farsani Zeinab
Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IR, Iran.
Discov Oncol. 2024 Jun 10;15(1):219. doi: 10.1007/s12672-024-01078-x.
Zinc finger antisense 1 (ZFAS1), a newly discovered long noncoding RNA, is expressed in various tissues and organs and has been introduced an oncogenic gene in human malignancies. In various cancers, ZFAS1 regulates apoptosis, cell proliferation, the cell cycle, migration, translation, rRNA processing, and spliceosomal snRNP assembly; targets signaling cascades; and interacts with transcription factors via binding to key proteins and miRNAs, with conflicting findings on its effect on these processes. ZFAS1 is elevated in different types of cancer, like colorectal, colon, osteosarcoma, and gastric cancer. Considering the ZFAS1 expression pattern, it also has the potential to be a diagnostic or prognostic marker in various cancers. The current review discusses the mode of action of ZFAS1 in various human cancers and its regulation function related to chemoresistance comprehensively, as well as the potential role of ZFAS1 as an effective and noninvasive cancer-specific biomarker in tumor diagnosis, prognosis, and treatment. We expected that the current review could fill the current scientific gaps in the ZFAS1-related cancer causative mechanisms and improve available biomarkers.
锌指反义RNA1（ZFAS1）是一种新发现的长链非编码RNA，在多种组织和器官中表达，在人类恶性肿瘤中被认为是一种致癌基因。在各种癌症中，ZFAS1可调节细胞凋亡、细胞增殖、细胞周期、迁移、翻译、核糖体RNA加工和剪接体小核核糖核蛋白组装；靶向信号级联反应；并通过与关键蛋白质和微小RNA结合与转录因子相互作用，但其对这些过程的影响存在相互矛盾的研究结果。ZFAS1在不同类型的癌症中表达升高，如结直肠癌、结肠癌、骨肉瘤和胃癌。鉴于ZFAS1的表达模式，它也有可能成为各种癌症的诊断或预后标志物。本综述全面讨论了ZFAS1在各种人类癌症中的作用模式及其与化疗耐药相关的调节功能，以及ZFAS1作为一种有效且非侵入性的癌症特异性生物标志物在肿瘤诊断、预后和治疗中的潜在作用。我们期望本综述能够填补目前在ZFAS1相关癌症致病机制方面的科学空白，并改进现有的生物标志物。
