Campbell Sydney L, Christofk Heather R
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA.
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
Cold Spring Harb Perspect Med. 2025 Jan 7;15(1):a041554. doi: 10.1101/cshperspect.a041554.
Tumor cells divide rapidly and dramatically alter their metabolism to meet biosynthetic and bioenergetic needs. Through studying the aberrant metabolism of cancer cells, other contexts in which metabolism drives cell state transitions become apparent. In this work, we will discuss how principles established by the field of cancer metabolism have led to discoveries in the contexts of physiology and tissue injury, mammalian embryonic development, and virus infection. We present specific examples of findings from each of these fields that have been shaped by the study of cancer metabolism. We also discuss the next important scientific questions facing these subject areas collectively. Altogether, these examples demonstrate that the study of "cancer metabolism" is indeed the study of cell metabolism in the context of a tumor, and undoubtedly discoveries from each of the fields discussed here will continue to build on each other in the future.
肿瘤细胞迅速分裂，并显著改变其新陈代谢以满足生物合成和生物能量需求。通过研究癌细胞的异常新陈代谢，新陈代谢驱动细胞状态转变的其他情况也变得明显起来。在这项工作中，我们将讨论癌症代谢领域所确立的原理是如何在生理学和组织损伤、哺乳动物胚胎发育以及病毒感染等背景下带来新发现的。我们展示了这些领域中每项研究因癌症代谢研究而产生的具体发现实例。我们还讨论了这些主题领域共同面临的下一个重要科学问题。总之，这些实例表明，“癌症代谢”研究实际上是在肿瘤背景下对细胞代谢的研究，而且毫无疑问，这里讨论的每个领域的发现未来都将继续相互促进。
