Hauer B, Grison D, Favier J P, Sacrez A
Ann Cardiol Angeiol (Paris). 1985 Feb;34(2):75-81.
The purpose of this study was to evaluate the ability of beta blocker therapy in decreasing the amount of necrosis during a first transmural myocardial infarction (as evidenced by a local and overall kinetic study using two-dimensional ultrasonography). Twenty patients were randomly placed into 2 groups. Ten patients received 15 mg of metoprolol intravenously followed by 200 mg daily of the drug orally. The results indicated that beta blockers are well tolerated clinically and hemodynamically, and that they significantly reduced the amount of necrosis (p less than 0.05 in anterior myocardial infarctions).
本研究的目的是评估β受体阻滞剂疗法在首次透壁性心肌梗死期间减少坏死量的能力（通过二维超声心动图进行局部和整体动力学研究来证明）。20名患者被随机分为2组。10名患者静脉注射15毫克美托洛尔，随后每天口服200毫克该药物。结果表明，β受体阻滞剂在临床和血流动力学方面耐受性良好，并且它们显著减少了坏死量（在前壁心肌梗死中p<0.05）。
