Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Nursing Department, Beijing Tiantan Hospital, Beijing, 100070, China.
Sci Rep. 2024 Jan 23;14(1):2013. doi: 10.1038/s41598-024-51878-y.
The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) and mortality remains uncertain. We aim to explore the potential correlation between systemic immune-inflammation index (SII) and these factors. We used data from 2011 to 2016 of National Health and Nutrition Examination Survey, and multivariate logistic regression and restricted cubic spline were employed. Subgroup and interaction analysis were conducted to recognize the consistency of the results. The association between SII and mortality was described by survival analysis. 6734 participants were enrolled, of whom 49.3% (3318) exhibited IR and 7.02% experienced mortality. Multivariate logistic regression revealed that individuals in the highest quartile (Q4) of SII had a significantly increased risk of IR compared to those in the lowest quartile (Q1). We then identified a linear association between SII and IR with an inflection point of 407, but may be influenced by gender. Similarly, compared to Q1, people whose SII at Q4 showed a higher all-cause and cardiovascular mortality. It showed a significant association between SII and both all-cause and cardiovascular mortality, but the results need to be interpreted with caution.
炎症在疾病的发生发展中起着重要作用，但新发现的炎症生物标志物与胰岛素抵抗（IR）和死亡率之间的确切关联仍不确定。我们旨在探讨全身免疫炎症指数（SII）与这些因素之间的潜在相关性。我们使用了 2011 年至 2016 年国家健康和营养调查的数据，并采用多元逻辑回归和限制立方样条进行分析。进行了亚组和交互分析以确认结果的一致性。通过生存分析描述了 SII 与死亡率之间的关系。共纳入 6734 名参与者，其中 49.3%（3318 名）存在 IR，7.02%经历了死亡。多元逻辑回归显示，SII 最高四分位数（Q4）的个体与最低四分位数（Q1）相比，发生 IR 的风险显著增加。我们随后发现 SII 与 IR 之间存在线性关联，拐点为 407，但可能受到性别影响。同样，与 Q1 相比，SII 处于 Q4 的个体全因和心血管死亡率更高。SII 与全因和心血管死亡率均呈显著相关，但结果需谨慎解释。
