Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, 710126, Shaanxi, China.
Biomed Eng Online. 2024 Jun 10;23(1):53. doi: 10.1186/s12938-024-01248-6.
Metastasis is one of the main factors leading to the high mortality rate of gastric cancer. The current monitoring methods are not able to accurately monitor gastric cancer metastasis.
In this paper, we constructed a new type of hollow nanocomposites, @HMSN-Cy7.5-FA, which had a size distribution of approximately 100 nm and showed good stability in different liquid environments. The in vitro magnetic resonance imaging (MRI) results show that the nanocomposite has good response effects to the acidic microenvironment of tumors. The acidic environment can significantly enhance the contrast of -weighted MRI. The cellular uptake and endocytosis results show that the nanocomposite has good targeting capabilities and exhibits good biosafety, both in vivo and in vitro. In a gastric cancer nude mouse orthotopic metastatic tumor model, with bioluminescence imaging's tumor location information, we realized in vivo MRI/fluorescence imaging (FLI) guided precise monitoring of the gastric cancer orthotopic and metastatic tumors with this nanocomposite.
This report demonstrates that @HMSN-Cy7.5-FA nanocomposites is a promising nano-diagnostic platform for the precision diagnosis and therapy of gastric cancer metastasis in the future.
In vivo MRI/FLI imaging results show that the nanocomposites can achieve accurate monitoring of gastric cancer tumors in situ and metastases. BLI's tumor location information further supports the good accuracy of MRI/FLI dual-modality imaging. The above results show that the MHCF NPs can serve as a good nano-diagnostic platform for precise in vivo monitoring of tumor metastasis. This nanocomposite provides more possibilities for the diagnosis and therapy of gastric cancer metastases.
转移是导致胃癌高死亡率的主要因素之一。目前的监测方法无法准确监测胃癌转移。
本文构建了一种新型的中空纳米复合材料@HMSN-Cy7.5-FA，其粒径分布约为 100nm，在不同的液体环境中表现出良好的稳定性。体外磁共振成像（MRI）结果表明，该纳米复合材料对肿瘤酸性微环境具有良好的响应效果。酸性环境可以显著增强 T1 加权 MRI 的对比度。细胞摄取和内吞结果表明，该纳米复合材料具有良好的靶向能力，表现出良好的生物安全性，无论是在体内还是体外。在胃癌裸鼠原位转移肿瘤模型中，利用生物发光成像的肿瘤位置信息，我们利用该纳米复合材料实现了体内 MRI/荧光成像（FLI）引导的胃癌原位和转移肿瘤的精确监测。
本报告表明，@HMSN-Cy7.5-FA 纳米复合材料是一种有前途的纳米诊断平台，可用于未来胃癌转移的精确诊断和治疗。
体内 MRI/FLI 成像结果表明，该纳米复合材料能够实现对原位和转移胃癌肿瘤的精确监测。BLI 的肿瘤位置信息进一步支持了 MRI/FLI 双模式成像的良好准确性。上述结果表明，MHCF NPs 可以作为一种良好的纳米诊断平台，用于精确监测肿瘤转移的体内情况。这种纳米复合材料为胃癌转移的诊断和治疗提供了更多的可能性。
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