Sun Wenjie, Zhang Jiulong, Zhang Changchang, Wang Peng, Peng Chen, Shen Mingwu, Shi Xiangyang
State Key Laboratory for Modification of Chemical Fiber and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, People's Republic of China.
ACS Macro Lett. 2018 Feb 20;7(2):137-142. doi: 10.1021/acsmacrolett.7b00999. Epub 2018 Jan 5.
Development of sensitive contrast agents for positive magnetic resonance (MR) imaging of biosystems still remains a great challenge. Herein, we report a facile process to construct hybrid alginate (AG) nanogels (NGs) loaded with manganese oxide (MnO) nanoparticles (NPs) for enhanced tumor MR imaging. The obtained AG/PEI-MnO NGs with a mean size of 141.6 nm display excellent colloidal stability in aqueous solution and good cytocompatibility in the studied concentration range. Moreover, the hybrid NGs have a high relaxivity of 26.12 mM s, which is about 19.5 times higher than that of PEI-MnO NPs with PEI surface amine acetylated (PEI.Ac-MnO NPs). Furthermore, the AG/PEI-MnO NGs presented longer blood circulation time and better tumor MR imaging performances than PEI.Ac-MnO NPs. With the good biosafety confirmed by histological examinations, the developed AG/PEI-MnO NGs may be potentially used as an efficient contrast agent for enhanced MR imaging of different biosystems.
开发用于生物系统正电子磁共振（MR）成像的灵敏造影剂仍然是一个巨大的挑战。在此，我们报告了一种简便的方法来构建负载氧化锰（MnO）纳米颗粒（NPs）的杂化藻酸盐（AG）纳米凝胶（NGs），用于增强肿瘤MR成像。所获得的平均尺寸为141.6 nm的AG/PEI-MnO NGs在水溶液中表现出优异的胶体稳定性，并且在研究的浓度范围内具有良好的细胞相容性。此外，杂化NGs具有26.12 mM s的高弛豫率，这比PEI表面胺乙酰化的PEI-MnO NPs（PEI.Ac-MnO NPs）高约19.5倍。此外，AG/PEI-MnO NGs比PEI.Ac-MnO NPs具有更长的血液循环时间和更好的肿瘤MR成像性能。经组织学检查证实具有良好的生物安全性，所开发的AG/PEI-MnO NGs可能潜在地用作增强不同生物系统MR成像的有效造影剂。
