Department of Medical Sciences, Division of Internal Medicine and Chronobiology Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza",, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, 71013, Italy.
Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Cell Commun Signal. 2024 Jun 10;22(1):319. doi: 10.1186/s12964-024-01676-w.
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and membrane-bound enzyme-linked receptors, such as receptor tyrosine kinases and serine-threonine kinases. They prompt phosphorylation of tyrosine and serine-threonine residues and initiate downstream signaling pathways and priming of intracellular molecules that convey the signal in the cytoplasm and nucleus, with transcriptional activation of specific genes enriching cell growth and survival-related cascades. These cell processes are rhythmically driven by molecular clockworks endowed in every cell type and when deregulated play a crucial role in cancer onset and progression. Growth factors and their matching receptor-dependent signaling are frequently overexpressed and/or dysregulated in many cancer types. In this review we focus on the interplay between biological clocks and Growth Factor Receptor-dependent signaling in the context of carcinogenesis.
几种不同的信号通路通过配体与细胞表面和膜结合的酶联受体（如受体酪氨酸激酶和丝氨酸/苏氨酸激酶）的结合来调节细胞增殖和分化。它们促使酪氨酸和丝氨酸/苏氨酸残基磷酸化，并启动下游信号通路和细胞内分子的启动，将信号在细胞质和核内传递，特定基因的转录激活丰富了与细胞生长和存活相关的级联反应。这些细胞过程受到每个细胞类型中存在的分子时钟的周期性驱动，当失调时，它们在癌症的发生和发展中起着至关重要的作用。生长因子及其匹配的受体依赖性信号在许多癌症类型中经常过表达和/或失调。在这篇综述中，我们重点讨论了生物钟与生长因子受体依赖性信号在致癌作用中的相互作用。
