Cormane R H, Siddiqui A H, Westerhof W, Schutgens R B
Arch Dermatol Res. 1985;277(2):126-30. doi: 10.1007/BF00414110.
The administration of phenylalanine (Phe) combined with UVA exposure was found to be effective in vitiligo. Phe is an amino acid which constitutes part of the daily dietary protein, and when orally administered in a dose of 50 mg/kg body weight, it results in an elevated plasma level. Since peak concentrations of Phe in the blood are reached between 30 and 45 min after ingestion, UVA exposure was administered at this time. After 4 months (32 treatments) reasonable repigmentation preferentially occurred in the skin area of subcutaneous fat (adipose tissue). Apart from the repigmentation of hypo-pigmented macules, vitiligo patients can tolerate more sun than usual, especially at the vitiliginous lesion, and they experience no sunburn as a result of Phe-UVA therapy. Normal skin also tans very well.
发现给予苯丙氨酸（Phe）并结合紫外线A（UVA）照射对白癜风有效。苯丙氨酸是构成日常膳食蛋白质一部分的氨基酸，当以50毫克/千克体重的剂量口服时，会导致血浆水平升高。由于摄入后30至45分钟内血液中苯丙氨酸达到峰值浓度，此时给予UVA照射。4个月（32次治疗）后，皮下脂肪（脂肪组织）皮肤区域优先出现了合理的色素再生。除色素减退斑色素再生外，白癜风患者比平时更能耐受阳光，尤其是在白癜风皮损处，并且他们不会因苯丙氨酸 - UVA疗法而晒伤。正常皮肤也能很好地晒黑。
