Aleshire S L, Glick A D, Cruz V E, Bradley C A, Parl F F
Arch Pathol Lab Med. 1985 Apr;109(4):352-6.
Neuroblastoma in adults is uncommon. Previous reports have suggested that adult patients with neuroblastoma have a better prognosis than children with these tumors. We have examined the clinical features of eight adults with neuroblastoma and related these data to tumor histopathology and immunohistochemistry using an antibody to neuron-specific enolase. The results show that when children and adults with neuroblastoma are compared by stage, adults do not have a better prognosis. Adults tend to have a different anatomic distribution of primary tumor sites, with more frequent extra-abdominal sites than are seen in children. Neuroblastomas arising in adults are similar to those seen in children by containing neuron-specific enolase, an enzyme associated with cells of neuroectodermal origin. These findings show that adult neuroblastomas are similar to their childhood counterparts in clinical behavior and pathologic features.
成人神经母细胞瘤并不常见。先前的报告表明，患有神经母细胞瘤的成年患者比患有这些肿瘤的儿童预后更好。我们研究了8例成人神经母细胞瘤的临床特征，并使用神经元特异性烯醇化酶抗体将这些数据与肿瘤组织病理学和免疫组织化学相关联。结果表明，按分期比较儿童和成人神经母细胞瘤患者时，成人的预后并不更好。成人原发性肿瘤部位的解剖分布往往不同，腹部外部位比儿童更常见。成人发生的神经母细胞瘤与儿童所见的神经母细胞瘤相似，都含有神经元特异性烯醇化酶，这是一种与神经外胚层起源细胞相关的酶。这些发现表明，成人神经母细胞瘤在临床行为和病理特征上与其儿童期对应物相似。
