Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, China.
College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Mini Rev Med Chem. 2024;24(21):1884-1893. doi: 10.2174/0113895575294482240530154620.
Long noncoding RNA (lncRNA) is a non-coding RNA with a length of more than 200 nucleotides, involved in multiple regulatory processes in vivo, and is related to the physiology and pathology of human diseases. An increasing number of experimental results suggest that when lncRNA is abnormally expressed, it results in the development of tumors. LncRNAs can be divided into five broad categories: sense, antisense, bidirectional, intronic, and intergenic. Studies have found that some antisense lncRNAs are involved in a variety of human tumorigenesis. The newly identified ROR1-AS1, which functions as an antisense RNA of ROR1, is located in the 1p31.3 region of the human genome. Recent studies have reported that abnormal expression of lncRNA ROR1-AS1 can affect cell growth, proliferation, invasion, and metastasis and increase oncogenesis and tumor spread, indicating lncRNA ROR1-AS1 as a promising target for many tumor biological therapies. In this study, the pathophysiology and molecular mechanism of ROR1-AS1 in various malignancies are discussed by retrieving the related literature. ROR1-AS1 is a cancer-associated lncRNA, and studies have found that it is either over- or underexpressed in multiple malignancies, including liver cancer, colon cancer, osteosarcoma, glioma, cervical cancer, bladder cancer, lung adenocarcinoma, and mantle cell lymphoma. Furthermore, it has been demonstrated that lncRNA ROR1-AS1 participates in proliferation, migration, invasion, and suppression of apoptosis of cancer cells. Furthermore, lncRNA ROR1-AS1 promotes the development of tumors by up-regulating or downregulating ROR1-AS1 conjugates and various pathways and miR-504, miR-4686, miR-670-3p, and miR-375 sponges, etc., suggesting that lncRNA ROR1-AS1 may be used as a marker in tumors or a potential therapeutic target for a variety of tumors.
长链非编码 RNA（lncRNA）是一种长度超过 200 个核苷酸的非编码 RNA，参与体内的多种调控过程，与人类疾病的生理和病理有关。越来越多的实验结果表明，当 lncRNA 异常表达时，会导致肿瘤的发生。lncRNA 可以分为五类：正义、反义、双向、内含子和基因间。研究发现，一些反义 lncRNA 参与多种人类肿瘤的发生。新鉴定的 ROR1-AS1，作为 ROR1 的反义 RNA，位于人类基因组的 1p31.3 区域。最近的研究报道，lncRNA ROR1-AS1 的异常表达可影响细胞生长、增殖、侵袭和转移，增加致癌性和肿瘤扩散，表明 lncRNA ROR1-AS1 是许多肿瘤生物治疗的有前途的靶点。在本研究中，通过检索相关文献，讨论了 ROR1-AS1 在各种恶性肿瘤中的病理生理学和分子机制。ROR1-AS1 是一种癌相关 lncRNA，研究发现它在多种恶性肿瘤中过度表达或低表达，包括肝癌、结肠癌、骨肉瘤、神经胶质瘤、宫颈癌、膀胱癌、肺腺癌和套细胞淋巴瘤。此外，已经证明 lncRNA ROR1-AS1 通过上调或下调 ROR1-AS1 缀合物和各种途径以及 miR-504、miR-4686、miR-670-3p 和 miR-375 等，参与癌细胞的增殖、迁移、侵袭和凋亡抑制。此外，lncRNA ROR1-AS1 通过上调或下调 ROR1-AS1 缀合物和各种途径以及 miR-504、miR-4686、miR-670-3p 和 miR-375 等，参与癌细胞的增殖、迁移、侵袭和凋亡抑制。此外，lncRNA ROR1-AS1 通过上调或下调 ROR1-AS1 缀合物和各种途径以及 miR-504、miR-4686、miR-670-3p 和 miR-375 等，参与癌细胞的增殖、迁移、侵袭和凋亡抑制。此外，lncRNA ROR1-AS1 可能作为肿瘤标志物或多种肿瘤的潜在治疗靶点。
