Qu Yuhua, Cheng Yulu, Chen Fengming
Department of Anorectology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Disinfection Supply Center, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Nutr. 2024 May 28;11:1375252. doi: 10.3389/fnut.2024.1375252. eCollection 2024.
This study examines the correlation between caffeine consumption and the prevalence of colon cancer.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) for the years 2001 to 2014, we applied weighted logistic regression to evaluate the association between caffeine consumption and the prevalence of colon cancer. This analysis accounted for variables including age, gender, race, education, poverty income ratio, smoking status, alcohol consumption, and diabetes. The findings were expressed as weighted odds ratios (ORs) with accompanying 95% confidence intervals (CIs). The restricted cubic spline analysis was performed to exam the dose-dependent relationship.
The study included 27,637 participants, of which 144 were diagnosed with colon cancer and 27,493 served as controls. Individuals in the highest quartile (Q4) of caffeine consumption (Q4) displayed a significantly increased risk of colon cancer compared to those in the lowest quartile (Q1), with a weighted OR of 2.00 (95% CI: 1.11-3.59; = 0.022). Additionally, restricted cubic spline analysis indicated a significant correlation between higher caffeine intake and increased colon cancer risk, with an overall association -value of 0.007.
These findings suggest a potential relationship between higher levels of caffeine consumption and an increased risk of colon cancer. The dose-response relationship suggests a notable correlation at higher caffeine intake levels. Further investigations are warranted to confirm these results and elucidate potential underlying mechanisms.
本研究探讨咖啡因摄入量与结肠癌患病率之间的相关性。
利用2001年至2014年美国国家健康与营养检查调查（NHANES）的数据，我们应用加权逻辑回归来评估咖啡因摄入量与结肠癌患病率之间的关联。该分析考虑了年龄、性别、种族、教育程度、贫困收入比、吸烟状况、饮酒情况和糖尿病等变量。研究结果以加权比值比（OR）及其95%置信区间（CI）表示。进行受限立方样条分析以检验剂量依赖关系。
该研究纳入了27637名参与者，其中144人被诊断患有结肠癌，27493人作为对照。与咖啡因摄入量最低四分位数（Q1）的个体相比，咖啡因摄入量最高四分位数（Q4）的个体患结肠癌的风险显著增加，加权OR为2.00（95%CI：1.11 - 3.59；P = 0.022）。此外，受限立方样条分析表明，较高的咖啡因摄入量与结肠癌风险增加之间存在显著相关性，总体关联P值为0.007。
这些发现表明较高水平的咖啡因消费与结肠癌风险增加之间可能存在关联。剂量反应关系表明在较高的咖啡因摄入量水平上存在显著相关性。有必要进一步开展研究以证实这些结果并阐明潜在的潜在机制。
