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BCCUSP232 暴露于提取物后的生理和毒理反应。

Physiological and toxicological response of BCCUSP232 exposed to extracts.

机构信息

School of Sciences, Humanities and Languages, Department of Biotechnology, São Paulo State University (UNESP), Assis, São Paulo, Brazil.

Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.

出版信息

J Toxicol Environ Health A. 2024 Sep;87(17):701-717. doi: 10.1080/15287394.2024.2366320. Epub 2024 Jun 12.

DOI:10.1080/15287394.2024.2366320
PMID:38865103
Abstract

is one of the most predominant freshwater bloom-forming cyanobacterium found globally which is capable of producing toxic secondary metabolites including microcystins that might intoxicate animals and humans when contaminated water or food is ingested. Aubl is one of the plants that might possess bioactive compounds capable of controlling growth and reproduction of . The present study aimed to determine the presence of bioactive compounds in extracts and determine alterations occurred in growth and reproduction of when exposed to these plant extracts. In addition, this investigation aimed to examine the influence of on antioxidant enzymes detected in . The results obtained demonstrated that the aqueous and ethanolic extracts of presented potential for control of cyanobacteria populations, exhibiting algicidal action on as well as interfering in antioxidant enzymes activities and parameters associated with oxidative stress. Phytochemical analyses demonstrated the presence of polyphenols and flavonoids content in both extracts. In addition, application of extracts did not produce cytogenotoxicity and/or mutagenicity utilizing test. Therefore, further studies are needed in order to identify and characterize the compounds responsible for these effects on and provide information regarding the possible application of in the treatment of drinking water.

摘要

鱼腥藻是全球最主要的淡水蓝藻水华形成藻之一,能够产生微囊藻毒素等有毒次生代谢物,当污染的水或食物被摄入时,可能会使动物和人类中毒。鱼腥藻是一种可能含有生物活性化合物的植物,能够控制 的生长和繁殖。本研究旨在确定鱼腥藻提取物中是否存在生物活性化合物,并确定暴露于这些植物提取物后 生长和繁殖的变化。此外,本研究旨在检查 对 中检测到的抗氧化酶的影响。研究结果表明,鱼腥藻的水提物和醇提物具有控制蓝藻种群的潜力,对 表现出杀藻作用,并干扰抗氧化酶活性和与氧化应激相关的参数。植物化学分析表明,两种提取物均含有多酚和类黄酮。此外,利用 试验表明,鱼腥藻提取物的应用不会产生细胞遗传毒性和/或致突变性。因此,需要进一步研究以鉴定和表征对 产生这些影响的化合物,并提供有关 可能在饮用水处理中应用的信息。

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