Shimada H, Aoyama C, Chiba T, Newton W A
Hum Pathol. 1985 May;16(5):471-6. doi: 10.1016/s0046-8177(85)80085-x.
Pathologic prognostic factors in 36 undifferentiated neuroblastomas were studied by an immunohistochemical staining technique with anti-S-100 protein antibody. Nuclear abnormalities of neuroblastic cells (mitosis and karyorrhexis/5,000 cells [MKI]), the incidence of S-100 protein-positive cells in the supportive stroma, and the age of the patients at diagnosis were analyzed both individually and in combination. Based on the evaluation of these factors, two prognostic subgroups were identified for these tumors. Tumors for which the prognosis was good (all nine patients alive) occurred in younger patients (younger than 1.5 years), showed low (less than 100) or intermediate (100 to 200) MKI, and had positive to intensely positive staining for S-100 protein. Cases in which the prognosis was poor (7 per cent survival) had single or multiple factors of high (greater than 200) MKI and/or absent or weak staining for S-100 protein and/or older age (older than 1.5 years) at diagnosis. These results were compared with other clinical information.
采用抗S-100蛋白抗体免疫组织化学染色技术，对36例未分化神经母细胞瘤的病理预后因素进行了研究。对神经母细胞的核异常情况（有丝分裂和核溶解/5000个细胞[MKI]）、支持性基质中S-100蛋白阳性细胞的发生率以及诊断时患者的年龄进行了单独分析和综合分析。基于对这些因素的评估，为这些肿瘤确定了两个预后亚组。预后良好的肿瘤（所有9例患者均存活）发生在较年轻的患者（小于1.5岁）中，显示低（小于100）或中等（100至200）MKI，且S-100蛋白染色呈阳性至强阳性。预后较差的病例（生存率为7%）在诊断时有单一或多个高（大于200）MKI和/或S-100蛋白染色缺失或弱阳性和/或年龄较大（大于1.5岁）的因素。将这些结果与其他临床信息进行了比较。
