Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Biotechnology, Yonsei University, College of Life Science and Biotechnology, Seoul 03722, Republic of Korea.
KnA co. Ltd., Yongin-si 16942, Republic of Korea.
Food Chem. 2024 Oct 30;456:139872. doi: 10.1016/j.foodchem.2024.139872. Epub 2024 May 27.
The release of hydrogen cyanide (HCN) after food ingestion can pose a serious health risk to consumers. This study aimed to simultaneously quantify four cyanogenic glycosides (lotaustralin, prunasin, taxiphyllin, and dhurrin) using liquid chromatography-tandem mass spectrometry. The analysis scope extended beyond agricultural products to various consumer foods to estimate dietary exposure to cyanogenic glycosides and assess its risk levels. The major exposure sources are cassava chips (lotaustralin), apples (seeds) (prunasin and dhurrin), and Prunus mume axis (taxiphyllin). In addition to quantifying specific cyanogenic glycosides, this study proposed the development of a preliminary risk assessment framework based on the dietary exposure assessment and the calculation of theoretical levels of HCN derived from cyanogenic glycoside concentrations. In the absence of established guidelines for the permissible intake of foods containing cyanogenic glycosides, this study provides initial guidance for assessing the risks associated with a range of commonly consumed foods.
食物摄入后释放的氰化氢（HCN）可能会对消费者的健康造成严重威胁。本研究旨在使用液相色谱-串联质谱法同时定量四种生氰糖苷（澳洲茄边碱、苦杏仁苷、紫杉叶素和亚麻苦苷）。分析范围不仅涵盖农产品，还包括各种消费食品，以评估生氰糖苷的膳食暴露情况并评估其风险水平。主要的暴露源是木薯薯片（澳洲茄边碱）、苹果（种子）（苦杏仁苷和亚麻苦苷）和李属植物轴（紫杉叶素）。除了定量特定的生氰糖苷外，本研究还提出了基于膳食暴露评估和从生氰糖苷浓度计算理论 HCN 水平的初步风险评估框架的开发。在没有含生氰糖苷食物可摄入限量标准的情况下，本研究为评估一系列常见消费食品的相关风险提供了初步指导。
