Zhang Huifeng, Xu Yaying, Chen Lele
Department of Cardiovascular, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Department of Endocrinology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Front Endocrinol (Lausanne). 2025 May 22;16:1541294. doi: 10.3389/fendo.2025.1541294. eCollection 2025.
Inflammation is involved in the progression of overactive bladder (OAB). This study aimed to investigate the association between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and OAB.
Data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were analyzed to examine the relationship between NHR and OAB. Multivariable logistic regression model was used to estimate the association between NHR and OAB, along with restricted cubic spline regression to assess the dose-response relationship. Additionally, subgroup analyses were conducted.
Among 29,315 participants, 5,815 had OAB. After covariate adjustment, we found that NHR was positively associated with the odds of OAB. Notably, the relationship between NHR and OAB was nonlinear. There was a threshold at NHR = 2.85. When NHR < 2.85, no significant association was observed; when NHR ≥ 2.85, a positive association emerged. Subgroup and interaction analyses further revealed that the link between NHR and OAB was stronger in obese participants.
Our results indicate a nonlinear association between NHR and OAB. When NHR is ≥ 2.85, there is a strong positive association between NHR and the odds of OAB. The interaction between obesity and NHR further increases the prevalence of OAB. Prospective and multicenter studies are needed in the future to elucidate the potential mechanism underlying the association between NHR and OAB and determine the causal relationship.
炎症参与了膀胱过度活动症（OAB）的进展。本研究旨在探讨中性粒细胞与高密度脂蛋白胆固醇比值（NHR）与OAB之间的关联。
分析了2005年至2018年美国国家健康与营养检查调查（NHANES）七个周期的数据，以研究NHR与OAB之间的关系。使用多变量逻辑回归模型估计NHR与OAB之间的关联，并采用受限立方样条回归评估剂量反应关系。此外，还进行了亚组分析。
在29315名参与者中，5815人患有OAB。经过协变量调整后，我们发现NHR与OAB的患病几率呈正相关。值得注意的是，NHR与OAB之间的关系是非线性的。NHR = 2.85时存在一个阈值。当NHR < 2.85时，未观察到显著关联；当NHR≥2.85时，出现正相关。亚组和交互分析进一步表明，肥胖参与者中NHR与OAB之间的联系更强。
我们的结果表明NHR与OAB之间存在非线性关联。当NHR≥2.85时，NHR与OAB的患病几率之间存在很强的正相关。肥胖与NHR之间的相互作用进一步增加了OAB的患病率。未来需要进行前瞻性和多中心研究，以阐明NHR与OAB之间关联的潜在机制，并确定因果关系。
