Ehsani Zohreh, Salehifar Ebrahim, Habibi Emran, Alizadeh-Navaei Reza, Moosazadeh Mahmoud, Tabrizi Nasim, Zaboli Ehsan, Omrani-Nava Versa, Shekarriz Ramin
Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Hematol Oncol Stem Cell Res. 2024 Apr 1;18(2):165-173. doi: 10.18502/ijhoscr.v18i2.15372.
Chemotherapy-induced peripheral neuropathy (CIPN) is a significant cancer treatment side effect that can influence both quality of life and treatment course. Melissa Officinalis (MO), due to its high content of flavonoids, has antioxidant, anti-inflammatory, and neuroprotective properties. The cancer patients diagnosed with CIPN attended a referral center in Sari (Iran). The hydroalcoholic extract of MO leaves was extracted by the maceration method. The control group received a placebo along with gabapentin as the standard treatment, and the intervention group received 500 mg Melissa officinalis 2 times daily for 3 months plus gabapentin. Patients were evaluated at the baseline and 3 months later, according to Common Terminology Criteria for Adverse Effects (CTCAE) and EORTC QLQ-C30 (Integrated System for Quality of Life Assessment). Results: A total of 40 patients were considered as group D (intervention group), and 35 patients completed the study. Out of 40 subjects in the placebo group (P), 3 patients could not tolerate the drug due to gastrointestinal disturbances. The final values of CTCAE showed a statistically significant difference (p=0.010). Indicators related to the quality of life in both groups showed a significant improvement. In the intervention group, the pain perception and diarrhea experience were significantly reduced. Conclusion: Quality of life indicators were improved by prescribing gabapentin with and without Melissa officinalis. The addition the chemotherapy regimen may improve diarrhea and pain perception.
化疗引起的周围神经病变（CIPN）是一种严重的癌症治疗副作用，会影响生活质量和治疗进程。由于富含黄酮类化合物，蜜蜂花具有抗氧化、抗炎和神经保护特性。被诊断为CIPN的癌症患者前往伊朗萨里的一家转诊中心就诊。采用浸渍法提取蜜蜂花叶的水醇提取物。对照组接受安慰剂加加巴喷丁作为标准治疗，干预组每天2次服用500毫克蜜蜂花，持续3个月，外加加巴喷丁。根据不良事件通用术语标准（CTCAE）和欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30，生活质量评估综合系统）在基线和3个月后对患者进行评估。结果：共有40名患者被纳入D组（干预组），35名患者完成了研究。在安慰剂组（P）的40名受试者中，3名患者因胃肠道不适无法耐受该药物。CTCAE的最终值显示出统计学上的显著差异（p = 0.010）。两组中与生活质量相关的指标均有显著改善。在干预组中，疼痛感知和腹泻经历显著减少。结论：加用或不加用蜜蜂花开具加巴喷丁均可改善生活质量指标。在化疗方案中添加蜜蜂花可能会改善腹泻和疼痛感知。
