Unit of Research in Ecology of Health (URES), Franceville Interdisciplinary Center for Medical Research (CIRMF), BP 769 Franceville, Gabon; Central African Regional Doctoral School in Tropical Infectiology (EDR), BP 876 Franceville, Gabon.
Central African Regional Doctoral School in Tropical Infectiology (EDR), BP 876 Franceville, Gabon; Unit of Evolution, Epidemiology and Parasite Resistance (UNEEREP), Franceville Interdisciplinary Center for Medical Research (CIRMF), BP 769 Franceville, Gabon.
J Infect Public Health. 2024 Jul;17(7):102459. doi: 10.1016/j.jiph.2024.05.047. Epub 2024 Jun 3.
The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control.
本研究旨在阐明 1980 年以来加蓬疟疾流行病学的时空变化。为此，我们使用了五个数据库，收集并确定了 1980 年至 2023 年间发表的所有关于疟疾发病率、抗疟药物耐药性、抗疟药物耐药标志物和杀虫剂耐药标志物的研究。研究结果表明，加蓬继续面临疟疾这一紧迫的公共卫生问题，其发病率持续居高不下。尽管已停止使用氯喹，但 CQ 耐药标志物仍持续存在，而 SP 耐药标志物的出现频率很高，达到 100%，同时 ACT 仍然有效。此外，最近的研究发现，Kdr-w 和 Kdr-e 杀虫剂耐药标志物的频率在 25%至 100%之间。Ace1R 突变的报告频率为 0.4%。总之，ACT 的疗效仍高于世界卫生组织推荐的阈值。有机磷和氨基甲酸酯类药物可能为病媒控制提供替代选择。
