Shaw J H, Wolfe R R
Metabolism. 1985 May;34(5):442-9. doi: 10.1016/0026-0495(85)90210-0.
The kinetics and oxidation of glucose and free fatty acid (FFA) metabolism were assessed in control and Escherichia coli septicemic dogs by using primed, constant infusions of U-14C-glucose and 1,2, 13C-palmitic acid. In the controls, the infusion of glucose suppressed endogenous glucose production completely, whereas, in the septic dogs, only a 30% suppression of glucose production occurred. The ability of the septic dogs to oxidize endogenous or exogenous glucose was decreased significantly. The basal rate of appearance of FFA was significantly higher in the septic dogs, but their ability to oxidize FFA was comparable to that of the control dogs; therefore, the basal rate of FFA oxidation was higher in the septic dogs. These studies indicate that septic dogs have a decreased capacity to oxidize glucose, but that they retain their ability to oxidize long-chain fatty acids. Because the rate of lipolysis was increased in sepsis, lipid was the predominate energy substrate in this septic model.
通过使用初剂量、持续输注U-14C-葡萄糖和1,2,13C-棕榈酸，评估了对照犬和大肠杆菌败血症犬体内葡萄糖和游离脂肪酸（FFA）代谢的动力学及氧化情况。在对照犬中，输注葡萄糖可完全抑制内源性葡萄糖生成，而在败血症犬中，仅出现了30%的葡萄糖生成抑制。败血症犬氧化内源性或外源性葡萄糖的能力显著下降。败血症犬的FFA基础出现率显著更高，但其氧化FFA的能力与对照犬相当；因此，败血症犬的FFA氧化基础速率更高。这些研究表明，败血症犬氧化葡萄糖的能力下降，但仍保留氧化长链脂肪酸的能力。由于败血症时脂解速率增加，脂质是该败血症模型中的主要能量底物。
