Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Animal Nutrition, Department of Animal Physiology and Health, Hungarian University of Agriculture and Life Sciences, Guba Sándor Str. 40, Kaposvár 7400, Hungary.
Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Animal Nutrition, Department of Animal Physiology and Health, Hungarian University of Agriculture and Life Sciences, Guba Sándor Str. 40, Kaposvár 7400, Hungary; HUN-REN-MATE Mycotoxins in the Food Chain Research Group, Hungarian University of Agriculture and Life Sciences, Guba Sándor Str. 40, Kaposvár 7400, Hungary.
Toxicology. 2024 Aug;506:153860. doi: 10.1016/j.tox.2024.153860. Epub 2024 Jun 12.
Monitoring modifications in membrane lipids in association with external stimuli/agents, including fumonisins (FUMs), is a widely employed approach to assess cellular metabolic response/status. FUMs are prevalent fusariotoxins worldwide that have diverse structures with varying toxicity across species; nevertheless, they can induce metabolic disturbances and disease, including cancer. The capacity of FUMs to disrupt membrane lipids, demonstrated across numerous species and organs/tissues, is ascribed to a multitude of factors/events, which range from direct to indirect effects. Certain events are well established, whereas the potential consequences of others remain speculative. The most notable effect is their resemblance to sphingoid bases, which impacts the synthesis of ceramides leading to numerous changes in lipids' composition that are not limited to sphingolipids' composition of the membranes. The next plausible scenario involves the induction of oxidative stress, which is considered an indirect/secondary effect of FUMs. Additional modes of action include modifications of enzyme activities and nuclear signals related to lipid metabolism, although these are likely not yet fully comprehended. This review provides in-depth insight into the current state of these events and their potential mechanistic actions in modifying membrane lipids, with a focus on long-chain fatty acids. This paper also presents a detailed description of the reported modifications to membrane lipids by FUMs.
监测与外部刺激/试剂（包括伏马菌素 (FUMs)）相关的膜脂变化是评估细胞代谢反应/状态的常用方法。FUMs 是全球普遍存在的真菌毒素，具有不同的结构和不同物种的毒性；然而，它们会引起代谢紊乱和疾病，包括癌症。FUMs 能够破坏膜脂，这在许多物种和器官/组织中都得到了证明，这归因于多种因素/事件，包括直接和间接影响。某些事件已经得到证实，而其他事件的潜在后果仍在推测之中。最显著的影响是它们类似于鞘氨醇碱基，这会影响神经酰胺的合成，导致脂质组成发生许多变化，不仅限于膜鞘脂的组成。下一个合理的情况是诱导氧化应激，这被认为是 FUMs 的间接/次要影响。其他作用模式包括与脂质代谢相关的酶活性和核信号的改变，尽管这些可能尚未完全理解。本文深入探讨了这些事件的当前状态及其在改变膜脂方面的潜在机制作用，重点关注长链脂肪酸。本文还详细描述了 FUMs 对膜脂的报道修饰。
