Ali Omeralfaroug, Agyarko Edward, Gerencsér Zsolt, Balogh Krisztián, Mézes Miklós, Kovács Melinda, Maki Mohamed, Besselma Noureddine, Yakubu Haruna Gado, Szabó András
Agrobiotechnology and Precision Breeding for Food Security National Laboratory, Department of Animal Physiology and Health, Institute of Physiology and Animal Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary.
Institute of Agricultural and Food Economics, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary.
Front Vet Sci. 2025 Jun 10;12:1599805. doi: 10.3389/fvets.2025.1599805. eCollection 2025.
The study assessed the kidney, liver, and spleen of adult male rabbits ( = 10/group) in relation to fumonisin B series exposure (10 and 20 mg FB + FB + FB/kg feed) over a period of 65 days. The rabbit growth and feed intake remained unaffected; meanwhile, kidney and liver weights increased. The highest dose provided greater alterations in total phospholipid fatty acid profiles, particularly in the kidney (C20:5n3 and C18:0) and spleen (C18:1n7, C22:0, C20:4n6, and C20:5n3) than in the liver. Neither the kidneys nor the spleens demonstrated modifications in their antioxidant (glutathione and glutathione peroxidase) and lipid peroxidation (malondialdehyde) markers; however, there was a marked drop in the liver glutathione concentration and glutathione peroxidase of the group that administered 20 mg FBs/kg diet, while liver malondialdehyde levels remained unchanged. Serum clinical measures revealed elevated creatinine, total cholesterol, high-density lipoproteins, and gamma-glutamyl transferase activity at the highest FBs dose. Histological scores revealed mild nephrotoxicity and hepatotoxicity in the 20 mg FBs/kg group, accompanied by a mild to moderate lesion score in the spleen. Overall, FBs exposure elicited diverse organ-specific adverse effects, with severity increasing at higher doses. Despite these alterations, rabbits demonstrated adaptability to FBs over the study period, as indicated by steady growth performance.
该研究评估了成年雄性兔子（每组10只）在65天内接触伏马菌素B系列（10和20毫克FB₁+FB₂+FB₃/千克饲料）后的肾脏、肝脏和脾脏情况。兔子的生长和采食量未受影响；与此同时，肾脏和肝脏重量增加。最高剂量组对总磷脂脂肪酸谱的改变更大，尤其是在肾脏（C20:5n3和C18:0）和脾脏（C18:1n7、C22:0、C20:4n6和C20:5n3），而肝脏的改变较小。肾脏和脾脏的抗氧化剂（谷胱甘肽和谷胱甘肽过氧化物酶）及脂质过氧化（丙二醛）标志物均未显示出变化；然而，给予20毫克FB₃/千克日粮组的肝脏谷胱甘肽浓度和谷胱甘肽过氧化物酶显著下降，而肝脏丙二醛水平保持不变。血清临床指标显示，在最高FB₃剂量下，肌酐、总胆固醇、高密度脂蛋白和γ-谷氨酰转移酶活性升高。组织学评分显示，20毫克FB₃/千克组存在轻度肾毒性和肝毒性，脾脏伴有轻度至中度病变评分。总体而言，接触FB₃会引发多种器官特异性不良反应，且剂量越高，严重程度越高。尽管有这些改变，但兔子在研究期间对FB₃表现出适应性，生长性能稳定即表明了这一点。
