Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India.
Ophthalmology and Visual Sciences department, Khoo Teck Puat Hospital(KTPH), 90 Yishun Central, Singapore, Singapore.
Sci Rep. 2019 Aug 13;9(1):11728. doi: 10.1038/s41598-019-48040-4.
Central serous chorioretinopathy (CSCR) is characterised by choroidal hyperpermeability which results in neurosensory detachments (NSD) along with numerous retinal pigment epithelium (RPE) alterations such as RPE atrophy. Fundus autofluorescence (FAF) demonstrates the functionality of the RPE while multicolor imaging(MCI), by means of its three incident wavelengths, provides insight into clinical changes at various levels of the retina and choroid in CSCR. This study compares various clinical findings in CSCR (NSD, subretinal deposits, RPE atrophy, pigment epithelial detachments (PED) and pachyvessels) on the above mentioned imaging modalities both qualitatively and quantitatively. MCI showed higher mean cumulative area of RPE atrophic patches (6.3 ± 6.02 vs 5.7 ± 5.7 mm, p = 0.046), PED (1.3 ± 1.4 vs 1.1 ± 1.2 mm, p = 0.068) and NSD (17.2 ± 11.4 vs 15.7 ± 10.7 mm, p = 0.033). MCI demonstrated better defined lesions (NSD, PED, RPE atrophy) and more number of eyes with PED and pachyvessels in comparison to FAF.Both investigations had a 100% sensitivity in detecting NSD and 100% specificity for sub retinal deposits. This study demonstrates the ability of MCI to quantitatively and qualitatively define various clinical features in CSCR and the advantages it holds over FAF. MCI can hence be considered as a useful imaging modality in documenting and monitoring various structural changes in eyes with CSCR.
中心性浆液性脉络膜视网膜病变（CSCR）的特征是脉络膜通透性增加，导致神经感觉层脱离（NSD），同时伴有许多视网膜色素上皮（RPE）改变，如 RPE 萎缩。眼底自发荧光（FAF）显示 RPE 的功能，而多色成像（MCI）通过其三个入射波长，可以深入了解 CSCR 中视网膜和脉络膜各个层次的临床变化。本研究比较了 CSCR （NSD、视网膜下沉积物、RPE 萎缩、色素上皮脱离（PED）和厚血管）在上述成像方式下的各种临床发现，包括定性和定量两个方面。MCI 显示 RPE 萎缩斑块的平均累积面积（6.3±6.02 比 5.7±5.7mm，p=0.046）、PED（1.3±1.4 比 1.1±1.2mm，p=0.068）和 NSD（17.2±11.4 比 15.7±10.7mm，p=0.033）更大。与 FAF 相比，MCI 显示出更好定义的病变（NSD、PED、RPE 萎缩），并且更多的眼睛出现 PED 和厚血管。两种检查方法在检测 NSD 方面均具有 100%的敏感性，在检测视网膜下沉积物方面均具有 100%的特异性。本研究表明，MCI 能够定量和定性地定义 CSCR 中的各种临床特征，并且比 FAF 具有优势。因此，MCI 可以被认为是一种有用的成像方式，可用于记录和监测 CSCR 眼中的各种结构变化。
