Lamperi S, Carozzi S, Icardi A
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:928-31.
Serum erythropoietin increased in 55 patients after transplantation. The serum erythropoietin decreased when the haematocrit and haemoglobin reached high levels, indicating recovery of a feed-back control system. Despite the diminution of erythropoietin, six patients demonstrated a state of erythrocytosis while the in vitro cultures of BFU-e revealed high sensitivity to the reduced doses of erythropoietin, using monocyte-free T-lymphocyte-depleted peripheral blood. In polycythaemic transplanted patients it is possible that cellular interactions stimulate an early hyperproliferation of BFR-e with a greater erythropoietin sensitivity and a partial capacity to grow in the absence of erythropoietin.
55例患者移植后血清促红细胞生成素升高。当血细胞比容和血红蛋白达到高水平时，血清促红细胞生成素下降，表明反馈控制系统恢复。尽管促红细胞生成素减少，但6例患者表现为红细胞增多状态，而BFU-e的体外培养显示，使用无单核细胞、去除T淋巴细胞的外周血时，对促红细胞生成素剂量减少具有高敏感性。在移植后红细胞增多的患者中，细胞间相互作用可能刺激BFR-e早期过度增殖，使其对促红细胞生成素更敏感，并在无促红细胞生成素的情况下具有部分生长能力。
