Heilmann E, Gottschalk D, Gottschalk I, Lison A E
Clin Nephrol. 1983 Aug;20(2):94-7.
Mononuclear cells from peripheral blood of six patients with polycythemia after kidney transplantation were studied in methyl cellulose cultures using fetal calf serum with and without adding erythropoietin. Parallel tests were run with "synthetic medium". The data obtained were compared to those of patients with polycythemia vera and normal subjects. The erythropoietin independent proliferation in synthetic medium typical for polycythemia vera could not be found in patients with renal grafts. However, in the preparations with fetal calf serum without erythropoietin, a formation of erythroid colonies could be detected suggesting an increased sensitivity or proliferation of erythropoietically determined stem cells in patients with transplanted kidneys.
对6例肾移植后红细胞增多症患者外周血中的单核细胞，在添加和不添加促红细胞生成素的胎牛血清甲基纤维素培养物中进行研究。同时用“合成培养基”进行平行试验。将获得的数据与真性红细胞增多症患者和正常受试者的数据进行比较。在肾移植患者中未发现真性红细胞增多症典型的合成培养基中促红细胞生成素非依赖性增殖。然而，在不添加促红细胞生成素的胎牛血清制剂中，可检测到红系集落的形成，提示肾移植患者中促红细胞生成素定向干细胞的敏感性或增殖增加。
