Balikesir University, Faculty of Medicine, Department of Neurosurgery, Balikesir, Türkiye.
Turk Neurosurg. 2024;34(4):655-659. doi: 10.5137/1019-5149.JTN.44307-23.2.
To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.
This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities. The PON1 ratio, which represents the salt-stimulated PON/ arylesterase level, demonstrated a trimodal distribution. This ratio was applied to identify the different phenotypes; QQ, QR, and RR of each subject.
The LDH patients had lower PON1 activity than the healthy individuals (p < 0.05). LDH patients had a statistically significant QQ phenotype compared to the healthy subjects (p < 0.05).
LDH patients had statistically lower PON1 activity, suggesting that the low PON1 activity and PON1 QQ phenotype may be a risk factor for LDH occurrence.
比较腰椎间盘突出症（LDH）患者与健康个体之间的对氧磷酶 1（PON1）活性和表型分布。
本研究纳入了 40 例 LDH 患者和 42 名健康个体。采用分光光度法测定血清 PON1 和芳基酯酶活性。PON1 比值表示盐刺激的 PON/芳基酯酶水平，呈三峰分布。该比值用于确定每个受试者的不同表型；QQ、QR 和 RR。
LDH 患者的 PON1 活性低于健康个体（p<0.05）。与健康受试者相比，LDH 患者的 QQ 表型具有统计学意义（p<0.05）。
LDH 患者的 PON1 活性有统计学意义降低，提示低 PON1 活性和 PON1 QQ 表型可能是 LDH 发生的危险因素。
