Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Mol Metab. 2024 Aug;86:101966. doi: 10.1016/j.molmet.2024.101966. Epub 2024 Jun 12.
Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways. As such, inhibition of the mitochondrial bioenergetic system by restricting metabolite availability, direct inhibition of the respiratory Complexes, altering organelle structure, or coupling efficiency may restrict carcinogenic potential and cancer progression.
Here, we review the role of bioenergetics as the principal conductor of energetic functions and carcinogenesis while highlighting the therapeutic potential of targeting mitochondrial functions.
Mitochondrial bioenergetics significantly contribute to cancer initiation and survival. As a result, therapies designed to limit oxidative efficiency may reduce tumor burden and enhance the efficacy of currently available antineoplastic agents.
通过提供腺苷三磷酸（ATP）和代谢中间产物以及控制氧化还原稳态，核心能量代谢的生物能量重塑对于癌细胞的发生、存活和进展至关重要。线粒体是进化上保守的细胞器，通过赋予能量可塑性和适应潜力来介导细胞存活。线粒体 ATP 合成与通过各种代谢途径产生的各种底物的氧化偶联。因此，通过限制代谢物可用性、直接抑制呼吸复合物、改变细胞器结构或偶联效率来抑制线粒体生物能量系统可能会限制致癌潜力和癌症进展。
在这里，我们回顾了生物能量学作为能量功能和致癌作用的主要导体的作用，同时强调了靶向线粒体功能的治疗潜力。
线粒体生物能量学对癌症的发生和存活有重要贡献。因此，旨在限制氧化效率的疗法可能会减少肿瘤负担并增强现有抗肿瘤药物的疗效。
