Wang Liya, Sun Bingying, Xu Ji, Cao Dan, Chen Yi, Xu Ying, Wu Dan
The Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.
Heliyon. 2024 May 29;10(11):e32114. doi: 10.1016/j.heliyon.2024.e32114. eCollection 2024 Jun 15.
BACKGROUND: Cervical intraepithelial neoplasia (CIN) encompasses a range of cervical lesions that are closely linked to cervical invasive carcinoma. Early detection and timely treatment of CIN are crucial for preventing the progression of the disease. However, no bibliometric analysis has been conducted in this area. This research aimed to employ bibliometric analysis to summarize the current research hotspots and estimate future research trends in the CIN field. METHODS: Publications related to CIN (2013-2023) were retrieved from the Science-Citation-Index-Expanded-of-Web-of-Science-Core-Collection. CiteSpace, VOSviewer, and the bibliometric-Online-Analysis-Platform-of-Literature-Metrology were employed to analyze the yearly research output, collaborating institutions or countries, leading researchers, principal journals, co-referenced sources, and emerging keywords. RESULTS: In total, 4677 articles on CIN that were published from 2013 to 2023 and met our criteria were extracted. Major publishing platforms were predominantly USA until 2017 when China emerged as the leading source of publications about CIN. The USA was the leading nation in international collaborations. The National-Cancer-Institute (NCI) was the institution with the most publications. Schiffman Mark produced the highest number of articles, with a total of 92. Ten major clusters were identified through co-cited keyword clustering, including prevalence, human papillomavirus, DNA methylation, p16, methylation, conization, HPV genotyping tests (VALGENT), deep learning, vaginal microbiome, and immunohistochemistry. Keyword burst analysis showed that photodynamic therapy and deep learning emerged as prominent research focal points with significant impact in resent three years. CONCLUSION: Global publications on CIN research showed a relatively stable trend over the past eleven years. Current research hotspots are deep learning and photodynamic therapy. This research offered organized data and insightful guidance for future studies, which may help better prevent, screen, and treat CIN.
背景：宫颈上皮内瘤变（CIN）涵盖了一系列与宫颈浸润癌密切相关的宫颈病变。CIN的早期检测和及时治疗对于预防疾病进展至关重要。然而，该领域尚未进行文献计量分析。本研究旨在运用文献计量分析总结CIN领域当前的研究热点，并预测未来的研究趋势。 方法：从科学网核心合集的科学引文索引扩展版中检索2013 - 2023年与CIN相关的出版物。使用CiteSpace、VOSviewer和文献计量学在线分析平台对年度研究产出、合作机构或国家、主要研究人员、主要期刊、共被引文献和新兴关键词进行分析。 结果：共提取了2013年至2023年发表的4677篇符合标准的关于CIN的文章。直到2017年之前，主要的出版平台以美国为主，之后中国成为关于CIN出版物的主要来源国。美国是国际合作中处于领先地位的国家。美国国立癌症研究所（NCI）是发表文章最多的机构。希夫曼·马克发表的文章数量最多，总计92篇。通过共被引关键词聚类确定了十个主要聚类，包括患病率、人乳头瘤病毒、DNA甲基化、p16、甲基化、锥切术、HPV基因分型检测（VALGENT）、深度学习、阴道微生物群和免疫组织化学。关键词突现分析表明，光动力疗法和深度学习在最近三年成为具有显著影响力的突出研究焦点。 结论：过去十一年全球关于CIN研究的出版物呈相对稳定的趋势。当前的研究热点是深度学习和光动力疗法。本研究为未来的研究提供了有条理的数据和有见地的指导，这可能有助于更好地预防、筛查和治疗CIN。
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