Department of Dermatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Lasers Surg Med. 2024 Aug;56(6):551-556. doi: 10.1002/lsm.23814. Epub 2024 Jun 18.
Freckles and lentigines are common pigmented problems which not only cause substantial cosmetic morbidity but also create psychosocial concern. The available modalities for the treatment of pigmented lesions are often unsatisfactory for patients, require a long treatment period, and often cause skin irritation. With the advent of lasers, safe and effective treatment options for epidermal pigmentation have become more varied for different Fitzpatrick skin types. We aimed to evaluate the efficacy and safety of 577-nm yellow laser in the treatment of pigmented epidermal lesions.
This study was carried out on 50 patients presented with pigmented epidermal lesions (25 presented with freckles and 25 presented with lentigines). Each patient received four treatment sessions with a 577-nm diode laser at 2-week intervals.
There was significant improvement in freckles and lentigines, as 23 out of 50 patients showed marked improvement, 11 patients showed moderate improvement, 10 patients showed mild improvement, and only six patients had no changes. Moreover, 23 patients were very satisfied, 18 patients were satisfied, and nine patients were not satisfied. As regards the safety of the 577-nm yellow laser, there was no significant adverse effect among patients except pain, erythema, and hyperpigmentation, which resolved within one month after treatment.
This study showed that the 577-nm yellow laser is an effective, safe, and well-tolerated device in the treatment of freckles and lentigines.
雀斑和黑子是常见的色素问题，不仅会造成严重的美容损伤，还会引起心理社会问题。现有的色素病变治疗方法往往不能令患者满意，需要很长的治疗周期，而且往往会引起皮肤刺激。随着激光的出现，不同 Fitzpatrick 皮肤类型的表皮色素沉着有了更多安全有效的治疗选择。我们旨在评估 577nm 黄色激光治疗表皮色素病变的疗效和安全性。
本研究纳入了 50 名患有表皮色素病变的患者（25 名雀斑患者，25 名黑子患者）。每位患者接受了 4 次 577nm 半导体激光治疗，间隔 2 周。
雀斑和黑子均有显著改善，50 名患者中 23 名患者有明显改善，11 名患者有中度改善，10 名患者有轻度改善，仅有 6 名患者无变化。此外，23 名患者非常满意，18 名患者满意，9 名患者不满意。577nm 黄色激光的安全性方面，除疼痛、红斑和色素沉着外，患者无明显不良反应，这些不良反应在治疗后 1 个月内消退。
本研究表明，577nm 黄色激光是治疗雀斑和黑子的一种有效、安全且耐受良好的设备。
