Huang Yuqing, Liu Xing, Zhang Mengli, Lin Tong
Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Dec 27;17:3027-3032. doi: 10.2147/CCID.S491489. eCollection 2024.
Freckles are common hyperpigmented diseases that commonly occur in Caucasians and Asians. Freckles often cause cosmetic and even psychosocial concerns. Various lasers with different wavelengths have been used to treat pigmented spots. This study aims to evaluate the efficacy and safety of a novel 730-nm Ti: Sapphire picosecond laser in the treatment of freckles in Chinese patients.
A total of 12 patients with freckles were enrolled. Patients underwent one laser treatment and were followed-up after eight weeks. Images were captured before treatment and at the eight-week follow-up, which were independently examined by two physicians to assess the treatment efficacy, including the lesion clearance rate and global aesthetic improvement scale. Patients recorded their pain and other adverse effects. Ex vivo human foreskins were treated with 730 nm picosecond lasers for one pass with a 3.75 J/cm and then stained with hematoxylin and eosin (H&E).
The average clearance rate as 74.46% and the mean GAIS as 4.13 ± 0.61. The pain scores were averaged at 3.08 ± 0.79. One patient exhibited hyperpigmentation (8.33%) and another patient developed hypopigmentation (8.33%) by the 8-week follow-up visit. A large number of uniform vacuoles were observed in the epidermal basal layer and the dermal papillae in the ex vivo foreskins, immediately after the treatment with 730-nm Ti: Sapphire picosecond laser. The vacuoles were uniformly sized, principally with 20-40 µm diameter.
The 730-nm Ti: Sapphire picosecond laser is safe and effective for treating freckles.
雀斑是常见的色素沉着性疾病，常见于白种人和亚洲人。雀斑常引起美容甚至心理社会问题。各种不同波长的激光已被用于治疗色素沉着斑。本研究旨在评估新型730纳米钛宝石皮秒激光治疗中国患者雀斑的疗效和安全性。
共纳入12例雀斑患者。患者接受一次激光治疗，并在8周后进行随访。在治疗前和8周随访时采集图像，由两名医生独立检查以评估治疗效果，包括皮损清除率和整体美学改善量表。患者记录他们的疼痛和其他不良反应。用730纳米皮秒激光以3.75 J/cm的能量密度对离体人包皮进行单次照射，然后用苏木精和伊红（H&E）染色。
平均清除率为74.46%，平均整体美学改善量表评分为4.13±0.61。疼痛评分平均为3.08±0.79。在8周随访时，1例患者出现色素沉着（8.33%），另1例患者出现色素减退（8.33%）。在用730纳米钛宝石皮秒激光治疗后，立即在离体包皮的表皮基底层和真皮乳头层观察到大量均匀的空泡。这些空泡大小均匀，主要直径为20 - 40微米。
730纳米钛宝石皮秒激光治疗雀斑安全有效。
