Hassanein Eman M, Szelényi Zoltán, Szenci Ottó
Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine Budapest, H-2225 Üllő, Hungary.
Animal and Fish Production Department, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt.
Animals (Basel). 2024 May 26;14(11):1575. doi: 10.3390/ani14111575.
The administration of GnRH and its agonists benefits various aspects of bovine reproductive programs, encompassing physiological stages such as estrous synchronization, post-insemination, pregnancy, and the postpartum period. The positive impact of GnRH administration in overcoming challenges like repeat breeder cows, early embryonic loss prevention, and the management of cystic ovarian disease (COD) is thoroughly surveyed. Furthermore, this review focuses on the significance of GnRH administration during the postpartum period, its role in ovulation induction, and how it enhances the productivity of embryo transfer (ET) programs. An emerging feature of this field is introduced, focusing on nano-drug delivery systems for GnRH agonists, and the potential benefits that may arise from such advancements are highlighted. While this review offers valuable insights into various applications of GnRH in bovine reproduction, it emphasizes the crucial need for further research and development in this field to advance reproductive efficiency and health management in dairy cattle.
促性腺激素释放激素（GnRH）及其激动剂的应用有益于牛繁殖计划的各个方面，涵盖发情同步、输精后、妊娠和产后等生理阶段。全面综述了GnRH应用在克服诸如屡配不孕母牛、预防早期胚胎损失以及治疗卵巢囊肿疾病（COD）等挑战方面的积极影响。此外，本综述着重探讨了产后时期GnRH应用的重要性、其在诱导排卵中的作用以及如何提高胚胎移植（ET）计划的效率。介绍了该领域的一个新特点，重点关注GnRH激动剂的纳米药物递送系统，并强调了此类进展可能带来的潜在益处。虽然本综述为GnRH在牛繁殖中的各种应用提供了有价值的见解，但强调了该领域进一步研究和开发的迫切需求，以提高奶牛的繁殖效率和健康管理水平。
