García-Gómora Santiago, Gómez-Verduzco Gabriela, Márquez-Mota Claudia C, Cortés-Cuevas Arturo, Vazquez-Mendoza Oscar Vicente, Ávila-González Ernesto
Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México 04510, Mexico.
Departamento de Nutrición Animal y Bioquímica, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad de México 04510, Mexico.
Animals (Basel). 2024 Jun 4;14(11):1675. doi: 10.3390/ani14111675.
Different levels of metabolizable energy (ME) and the inclusion of guanidinoacetic acid (GAA) in the diet of 53-week-old Lohmann LSL-CLASSIC hens were used to evaluate its effect on reproductive parameters, egg quality, intestinal morphology, and the immune response. Six diets were used in a 3 × 2 factorial design, with three levels of ME (2850, 2800, and 2750 kcal/kg), and with (0.08%) or without the inclusion of GAA. The addition of GAA to diets with low levels of ME increased ( < 0.05) egg production and egg mass. Moreover, hens fed with 2800 kcal/g without GAA had the highest concentration ( < 0.05) of serum interleukin IL-2, while those fed diets with the same amount of ME but supplemented with 0.08% GAA had the lowest concentration. Finally, the inclusion of 0.08% GAA increased ( < 0.05) the concentration of vascular endothelial growth factor (VEGF), regardless of the ME level in the diet. This study highlights the potential role of GAA in decreasing the energy level of ME (50-100 kcal/g) in the feeding of hens and in the modulation of specific immune responses. Further research is recommended to fully understand the mechanisms of action of GAA on the mechanism target of rapamycin and its relationship with the immune response.
采用不同水平的代谢能（ME）以及在53周龄罗曼LSL - CLASSIC母鸡日粮中添加胍基乙酸（GAA），来评估其对繁殖参数、蛋品质、肠道形态和免疫反应的影响。采用3×2析因设计的六种日粮，有三个ME水平（2850、2800和2750千卡/千克），且添加（0.08%）或不添加GAA。在低水平ME日粮中添加GAA可提高（P<0.05）产蛋量和蛋重。此外，饲喂不含GAA的2800千卡/克日粮的母鸡血清白细胞介素IL - 2浓度最高（P<0.05），而饲喂相同ME水平但添加0.08% GAA日粮的母鸡血清白细胞介素IL - 2浓度最低。最后，无论日粮中的ME水平如何，添加0.08% GAA均可提高（P<0.05）血管内皮生长因子（VEGF）的浓度。本研究突出了GAA在降低母鸡日粮中ME能量水平（50 - 100千卡/克）以及调节特定免疫反应方面的潜在作用。建议进一步研究以充分了解GAA对雷帕霉素作用靶点的作用机制及其与免疫反应的关系。
