Pettina Giorgia, Bucci Roberta, Mazzetti Antonio, Quartuccio Marco, Robbe Domenico, Pisu Maria Carmela
Department of Veterinary Science, University of Messina, Viale Palatucci 13, 98168 Messina, Italy.
Department of Veterinary Medicine, University of Teramo, Loc. Piano d'Accio, 64100 Teramo, Italy.
Animals (Basel). 2024 Jun 5;14(11):1683. doi: 10.3390/ani14111683.
The prostate is the only sexual gland of the male dog, and dihydrotestosterone (DHT) regulates its growth. In intact dogs, constant DHT stimulation results in benign prostatic hyperplasia (BPH) that can be treated with osaterone acetate (OSA). This study describes the effects of OSA treatment, detected by contrast-enhanced ultrasonography (CEUS), highlighting prostatic vascularization with a contrast agent composed of gas microbubbles. Fifteen dogs (2-8 years) of different sizes and breeds (4-30 kg) diagnosed with BPH are involved in the study. Before treatment (D), CPSE is measured (294.05 ± 115.97 ng/mL), and a B-mode ultrasound is performed (V = 2.80 ± 1.85), confirming BPH. CEUS highlights the length of the wash-in (11.93 ± 2.08 s) and wash-out (42.20 ± 6.99 s) phases of the contrast agent in the prostate and the presence of cysts and parenchymal alteration. Dogs are treated with OSA (0.5 mg/kg for 7 days) and reassessed after 21 days (D): CPSE and prostate volume are significantly ( < 0.001) reduced. The length of the wash-in (14.73 ± 2.54 s) and wash-out (51.13 ± 6.03 s) phases are significantly ( < 0.001) increased. The results confirm the effectiveness of the treatment, particularly the reduction in prostatic perfusion, confirmed by the increase in diffusion times of the contrast. Although preliminary, these findings are promising for the use of CEUS in monitoring dogs with BPH.
前列腺是公犬唯一的性腺，双氢睾酮（DHT）调节其生长。在未阉割的犬中，持续的DHT刺激会导致良性前列腺增生（BPH），可用醋酸奥生多龙（OSA）治疗。本研究描述了通过超声造影（CEUS）检测到的OSA治疗效果，突出了用由气体微泡组成的造影剂显示的前列腺血管形成。15只不同大小和品种（4 - 30千克）、年龄在2 - 8岁、被诊断为BPH的犬参与了该研究。治疗前（D），测量血清前列腺特异性酸性磷酸酶（CPSE）（294.05±115.97纳克/毫升），并进行B型超声检查（V = 2.80±1.85），以确认BPH。CEUS突出了造影剂在前列腺中的快速增强期（11.93±2.08秒）和消退期（42.20±6.99秒）的时长以及囊肿和实质改变的存在。犬用OSA（0.5毫克/千克，共7天）治疗，并在21天后（D）重新评估：CPSE和前列腺体积显著（<0.001）减小。快速增强期（14.73±2.54秒）和消退期（51.13±6.03秒）的时长显著（<0.001）增加。结果证实了治疗的有效性，尤其是前列腺灌注的减少，这通过造影剂扩散时间的增加得到证实。尽管是初步的，但这些发现对于CEUS用于监测患有BPH的犬很有前景。
