Department of Food and Nutrition, Poznan University of Physical Education, 61-871 Poznan, Poland.
Department of Biochemistry and Physiology, Poznan University of Physical Education, 61-871 Poznan, Poland.
Int J Mol Sci. 2024 May 21;25(11):5611. doi: 10.3390/ijms25115611.
Emerging research links the endocannabinoid system to gut microbiota, influencing nociception, mood, and immunity, yet the molecular interactions remain unclear. This study focused on the effects of probiotics on ECS markers-cannabinoid receptor type 2 (CB2) and fatty acid amide hydrolase (FAAH)-in dancers, a group selected due to their high exposure to physical and psychological stress. In a double-blind, placebo-controlled trial (ClinicalTrials.gov NCT05567653), 15 dancers were assigned to receive either a 12-week regimen of Rosell-52 and Rosell-17 or a placebo (PLA: = 10, PRO: = 5). There were no significant changes in CB2 (probiotic: 0.55 to 0.29 ng/mL; placebo: 0.86 to 0.72 ng/mL) or FAAH levels (probiotic: 5.93 to 6.02 ng/mL; placebo: 6.46 to 6.94 ng/mL; > 0.05). A trend toward improved sleep quality was observed in the probiotic group, while the placebo group showed a decline (PRO: from 1.4 to 1.0; PLA: from 0.8 to 1.2; = 0.07841). No other differences were noted in assessed outcomes (pain and fatigue). Probiotic supplementation showed no significant impact on CB2 or FAAH levels, pain, or fatigue but suggested potential benefits for sleep quality, suggesting an area for further research.
新兴研究将内源性大麻素系统与肠道微生物群联系起来，影响痛觉、情绪和免疫，但分子相互作用仍不清楚。本研究专注于益生菌对 ECS 标志物-大麻素受体 2 (CB2) 和脂肪酸酰胺水解酶 (FAAH) 的影响，选择舞者作为研究对象，是因为他们高度暴露于身心压力之下。在一项双盲、安慰剂对照试验（ClinicalTrials.gov NCT05567653）中，15 名舞者被分配接受为期 12 周的 Rosell-52 和 Rosell-17 或安慰剂（PLA： = 10，PRO： = 5）治疗。CB2 水平没有显著变化（益生菌：0.55 至 0.29ng/mL；安慰剂：0.86 至 0.72ng/mL）或 FAAH 水平（益生菌：5.93 至 6.02ng/mL；安慰剂：6.46 至 6.94ng/mL； > 0.05）。益生菌组的睡眠质量有改善的趋势，而安慰剂组则有所下降（PRO：从 1.4 降至 1.0；PLA：从 0.8 降至 1.2； = 0.07841）。在评估的结果（疼痛和疲劳）中没有观察到其他差异。益生菌补充剂对 CB2 或 FAAH 水平、疼痛或疲劳没有显著影响，但对睡眠质量有潜在益处，表明这是一个值得进一步研究的领域。
