Division of Molecular Bacteriology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Intercollegiate Faculty of Biotechnology, University of Gdańsk, 80-307 Gdańsk, Poland.
Int J Mol Sci. 2024 May 23;25(11):5662. doi: 10.3390/ijms25115662.
is a causative agent of antibiotic-associated diarrhea as well as pseudomembranous colitis. So far, all known bacteriophages infecting these bacteria are temperate, which means that instead of prompt lysis of host cells, they can integrate into the host genome or replicate episomally. While phages are capable of spontaneous induction and entering the lytic pathway, very little is known about the regulation of their maintenance in the state of lysogeny. In this study, we investigated the properties of a putative major repressor of the recently characterized phiCDKH01 bacteriophage. A candidate protein belongs to the XRE family and controls the transcription of genes encoding putative phage antirepressors, known to be involved in the regulation of lytic development. Hence, the putative major phage repressor is likely to be responsible for maintenance of the lysogeny.
是抗生素相关性腹泻和伪膜性结肠炎的病原体。到目前为止，所有已知的感染这些细菌的噬菌体都是温和的，这意味着它们不会立即裂解宿主细胞，而是可以整合到宿主基因组中或以附加体的形式复制。虽然噬菌体能够自发诱导并进入裂解途径，但对于它们在溶原状态下的维持的调控知之甚少。在这项研究中，我们研究了最近表征的phiCDKH01 噬菌体的一个假定主要阻遏物的特性。候选蛋白属于 XRE 家族，控制编码假定噬菌体反阻遏物的基因的转录，已知这些反阻遏物参与裂解发育的调控。因此，假定的主要噬菌体阻遏物可能负责溶原性的维持。
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