Department of Translational Neuroscience, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Cerebro Pharma Inc., 4-5-6-3F Minamikyuhojimachi, Chuo-ku, Osaka 541-0058, Japan.
Nutrients. 2024 May 23;16(11):1589. doi: 10.3390/nu16111589.
The rhizomes of Schott and Solander are widely used for treating amnesia in traditional Chinese medicine. In contrast, their leaves are usually discarded without their medicinal properties being known. Here, we found that the hot water extract of leaves improved cognition and tau pathology in model mice of frontotemporal dementia, similar to or even better than that of rhizomes. To explore the optimal method of processing, we made three preparations from dried leaves: hot water extract, extraction residue, and non-extracted simple crush powder. Among them, the simple crush powder had the strongest effect on tauopathy in mice. The crush powder also ameliorated Aβ and α-synuclein pathologies and restored cognition in mouse models of Alzheimer's disease and dementia with Lewy bodies. These findings suggest the potential of / leaves as a dietary source for dementia prevention and reveal that simple crushing is a better way to maximize their efficacy.
姜科植物石虎或益智的根茎在传统中药中被广泛用于治疗健忘症。相比之下，它们的叶子通常被丢弃，而其药用特性却不为人知。在这里，我们发现叶子的热水提取物改善了额颞痴呆模型小鼠的认知和 tau 病理学，其效果与根茎相当，甚至更好。为了探索最佳的加工方法，我们从干叶中制备了三种制剂：热水提取物、提取残渣和未提取的简单粉碎粉末。其中，简单粉碎粉末对小鼠 tau 病的作用最强。粉碎粉末还改善了阿尔茨海默病和路易体痴呆模型小鼠的 Aβ 和 α-突触核蛋白病理学，并恢复了认知。这些发现表明，/叶子可能是预防痴呆的一种饮食来源，并揭示了简单粉碎是最大限度发挥其功效的更好方法。
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