Department of Nutrition, Faculty of Pharmacy, Saint Joseph University, Damascus Street, Beirut P.O. Box 11-5076, Lebanon.
Department of Human Nutrition, College of Health Sciences, QU-Health, Qatar University, Doha 2713, Qatar.
Nutrients. 2024 May 30;16(11):1701. doi: 10.3390/nu16111701.
Spirulina () is reported to play a role in improving nonalcoholic fatty liver disease (NAFLD) and intestinal microbiota (IM). To study spirulina's effects in the improvement of NAFLD characteristics, IM, and pancreatic-renal lesions induced by a fructose-enriched diet, 40 Wistar healthy male rats, weighing 200-250 g, were randomly divided into four groups of 10, and each rat per group was assigned a diet of equal quantities (20 g/day) for 18 weeks. The first control group (CT) was fed a standardized diet, the second group received a 40% fructose-enriched diet (HFr), and the third (HFr-S5) and fourth groups (HFr-S10) were assigned the same diet composition as the second group but enriched with 5% and 10% spirulina, respectively. At week 18, the HFr-S10 group maintained its level of serum triglycerides and had the lowest liver fat between the groups. At the phylae and family level, and for the same period, the HFr-S10 group had the lowest increase in the ratio and the and the highest fecal alpha diversity compared to all other groups ( < 0.05). These findings suggest that at a 10% concentration, spirulina could be used in nutritional intervention to improve IM, fatty liver, metabolic, and inflammatory parameters associated with NAFLD.
螺旋藻被报道在改善非酒精性脂肪肝（NAFLD）和肠道微生物群（IM）方面发挥作用。为了研究螺旋藻对改善果糖富集饮食诱导的 NAFLD 特征、IM 和胰肾病变的影响，将 40 只体重 200-250g 的 Wistar 健康雄性大鼠随机分为 4 组，每组 10 只，每组大鼠分配等量（20g/天）的饮食，共 18 周。第一对照组（CT）喂食标准饮食，第二组接受 40%果糖富集饮食（HFr），第三组（HFr-S5）和第四组（HFr-S10）则接受与第二组相同的饮食组成，但分别富含 5%和 10%的螺旋藻。第 18 周时，HFr-S10 组的血清甘油三酯水平保持不变，各组中肝脂肪含量最低。在门和科水平上，并且在同一时期，与所有其他组相比，HFr-S10 组的 比值和 增加最低，粪便 alpha 多样性最高（<0.05）。这些发现表明，在 10%的浓度下，螺旋藻可用于营养干预，以改善与 NAFLD 相关的 IM、脂肪肝、代谢和炎症参数。
