基于人体空间电场建模的优化经颅电刺激研究进展
Perspectives on Optimized Transcranial Electrical Stimulation Based on Spatial Electric Field Modeling in Humans.
作者信息
Gomez-Tames Jose, Fernández-Corazza Mariano
机构信息
Department of Medical Engineering, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan.
出版信息
J Clin Med. 2024 May 24;13(11):3084. doi: 10.3390/jcm13113084.
: Transcranial electrical stimulation (tES) generates an electric field (or current density) in the brain through surface electrodes attached to the scalp. Clinical significance has been demonstrated, although with moderate and heterogeneous results partly due to a lack of control of the delivered electric currents. In the last decade, computational electric field analysis has allowed the estimation and optimization of the electric field using accurate anatomical head models. This review examines recent tES computational studies, providing a comprehensive background on the technical aspects of adopting computational electric field analysis as a standardized procedure in medical applications. : Specific search strategies were designed to retrieve papers from the Web of Science database. The papers were initially screened based on the soundness of the title and abstract and then on their full contents, resulting in a total of 57 studies. : Recent trends were identified in individual- and population-level analysis of the electric field, including head models from non-neurotypical individuals. Advanced optimization techniques that allow a high degree of control with the required focality and direction of the electric field were also summarized. There is also growing evidence of a correlation between the computationally estimated electric field and the observed responses in real experiments. : Computational pipelines and optimization algorithms have reached a degree of maturity that provides a rationale to improve tES experimental design and a posteriori analysis of the responses for supporting clinical studies.
经颅电刺激(tES)通过连接在头皮上的表面电极在大脑中产生电场(或电流密度)。尽管部分结果因对输送电流缺乏控制而呈现出中等程度且参差不齐,但已证明其具有临床意义。在过去十年中,计算电场分析已能够使用精确的头部解剖模型来估计和优化电场。本综述考察了近期的经颅电刺激计算研究,为将计算电场分析作为医学应用中的标准化程序的技术方面提供了全面的背景。
设计了特定的检索策略,以从科学网数据库中检索论文。这些论文首先根据标题和摘要的合理性进行筛选,然后再根据其全文内容进行筛选,最终共得到57项研究。
在电场的个体水平和群体水平分析中发现了近期趋势,包括来自非典型个体的头部模型。还总结了能够对电场所需的聚焦性和方向进行高度控制的先进优化技术。越来越多的证据表明,计算估计的电场与实际实验中观察到的反应之间存在相关性。
计算流程和优化算法已经达到了一定的成熟度,这为改进经颅电刺激实验设计以及对反应进行事后分析以支持临床研究提供了理论依据。