Donovan T E, Gandara B K, Nemetz H
J Prosthet Dent. 1985 Apr;53(4):525-31. doi: 10.1016/0022-3913(85)90640-7.
Data from a survey of 495 dentists indicate that most dentists used the mechanical-chemical method of gingival-deflection; 79.39% of those used cord containing epinephrine. It can be concluded that potentially significant amounts of epinephrine can be absorbed systemically from the local anesthetic solution, that secretion of endogenous epinephrine in response to stress occurs, often at levels sufficient to cause measurable changes in hemodynamic variables, and that absorption of epinephrine from impregnated strings occurs. The amount of absorption will vary with the exposure of the vascular bed, the length and concentration of the impregnated cord, and the length of time of application. It is possible that the actual total amount of circulating catecholamine would be cumulative, and the corresponding cardiovascular response would be related to the total amount of epinephrine in the bloodstream, regardless of the source. When the fact that we usually have inadequate data on the cardiovascular status of our patients is considered, as well as the tendency to make impressions of multiple prepared teeth, the continued use of epinephrine cord in dentistry must be viewed with alarm. Equally effective astringent gingival deflection agents such as alum, aluminum sulfate, and aluminum chloride exert no systemic effects. Therefore, there is little indication for use of epinephrine-containing retraction cords. Adequate medical evaluation, careful use of anesthetics that contain epinephrine, and sedative techniques when indicated will assure the safety of our patients.
一项对495名牙医的调查数据表明,大多数牙医采用机械 - 化学方法进行牙龈移位;其中79.39%的人使用含肾上腺素的龈线。可以得出结论,局部麻醉溶液中的肾上腺素可能会被大量吸收入全身,对应激反应分泌的内源性肾上腺素也会出现,且其水平常常足以引起血液动力学变量的可测量变化,同时从浸渍线中吸收肾上腺素的情况也会发生。吸收量会因血管床暴露情况、浸渍线的长度和浓度以及应用时间的长短而有所不同。循环儿茶酚胺的实际总量可能会累积,相应的心血管反应会与血液中肾上腺素的总量相关,而不论其来源如何。考虑到我们通常对患者心血管状况的数据不足,以及制备多颗牙齿印模的倾向,牙科领域持续使用含肾上腺素的龈线必须引起警惕。同样有效的收敛性牙龈移位剂,如明矾、硫酸铝和氯化铝,不会产生全身影响。因此,几乎没有使用含肾上腺素收缩龈线的指征。进行充分的医学评估、谨慎使用含肾上腺素的麻醉剂以及在必要时采用镇静技术将确保我们患者的安全。