Park Hye-Jin, Thapa Ngeemasara, Bae Seongryu, Yang Ja-Gyeong, Choi Jaewon, Noh Eun-Seon, Park Hyuntae
Department of Healthcare and Science, Dong-A University, Busan 49315, Republic of Korea.
J Clin Med. 2024 May 29;13(11):3207. doi: 10.3390/jcm13113207.
: This study examines the relationship between physical and mental function and frailty, independently and in conjunction with polypharmacy, among older adults. : This cross-sectional study consisted of 368 participants aged ≥60 years. The participants were categorized into either robust or frail groups using Fried's frailty phenotype. Physical functions were assessed using grip strength, gait speed, Timed Up and Go (TUG), the Five Chair Sit to Stand Test (FCSST) and the Six-Minute Walk Test (SMWT). Mental functions were assessed using cognitive function and depression. Cognitive function was measured using Mini-Mental State Examination (MMSE). Depression was assessed with the Korean version of the Short Geriatric Depression Scale (SGDS). : The mean age of study population was 75.4 years. In this population, we identified 78.8% ( = 290) robust participants and 21.2% ( = 78) frail participants. The study examined frailty status (frail vs. non-frail) and frailty with and without polypharmacy using multivariate logistic regressions, adjusting for age and sex. In the logistic regression model estimating the risk of frailty, after adjustments for age, sex, BMI, and number of medications, individuals with low SMWT showed a significantly increased risk of frailty, with an odds ratio (OR) of 8.66 and a 95% confidence interval (CI) of 4.55-16.48. Additionally, global cognitive function was associated with a 1.97-fold increase in frailty risk (95% CI: 1.02-3.67). Moreover, in models adjusted for age, sex, and BMI to assess frailty risk linked to polypharmacy, the TUG, SMWT, and SGDS all showed increased risks, with ORs of 3.65 (95% CI: 1.07-12.47), 5.06 (95% CI: 1.40-18.32), and 5.71 (95% CI: 1.79-18.18), respectively. : Physical function (SMWT, FCSST, TUG) and mental function (depression, cognition) were associated with frailty. By comprehensively examining these factors, we will gain valuable insights into frailty and enable more precise strategies for intervention and prevention.
本研究探讨了老年人身体和心理功能与衰弱之间的关系，以及它们单独或与多重用药共同作用时的情况。本横断面研究由368名年龄≥60岁的参与者组成。使用弗里德衰弱表型将参与者分为强壮组或衰弱组。通过握力、步速、计时起立行走测试（TUG）、五椅起立测试（FCSST）和六分钟步行测试（SMWT）评估身体功能。通过认知功能和抑郁评估心理功能。使用简易精神状态检查表（MMSE）测量认知功能。用韩国版简易老年抑郁量表（SGDS）评估抑郁情况。研究人群的平均年龄为75.4岁。在该人群中，我们确定了78.8%（n = 290）的强壮参与者和21.2%（n = 78）的衰弱参与者。该研究使用多因素逻辑回归分析，在调整年龄和性别后，研究了衰弱状态（衰弱与非衰弱）以及伴有和不伴有多重用药情况下的衰弱情况。在估计衰弱风险的逻辑回归模型中，在调整年龄、性别、体重指数和用药数量后，六分钟步行测试得分低的个体衰弱风险显著增加，优势比（OR）为8.66，95%置信区间（CI）为4.55 - 16.48。此外，整体认知功能与衰弱风险增加1.97倍相关（95% CI：1.02 - 3.67）。此外，在调整年龄、性别和体重指数以评估与多重用药相关的衰弱风险的模型中，计时起立行走测试、六分钟步行测试和韩国版简易老年抑郁量表均显示风险增加，OR分别为3.65（95% CI：1.07 - 12.47）、5.06（95% CI：1.40 - 18.32）和5.71（95% CI：1.79 - 18.18）。身体功能（六分钟步行测试、五椅起立测试、计时起立行走测试）和心理功能（抑郁、认知）与衰弱相关。通过全面研究这些因素，我们将获得有关衰弱的宝贵见解，并能够制定更精确的干预和预防策略。
