School of Healthcare Sciences, Cardiff University, University Hospital of Wales, Cardiff, CF14 4XN, UK.
College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
NPJ Prim Care Respir Med. 2022 Jul 6;32(1):24. doi: 10.1038/s41533-022-00287-7.
The Timed Up and Go (TUG) is a global measure of mobility and has the ability to detect frail individuals. Frail patients with chronic obstructive pulmonary disease (COPD) are usually undiagnosed. We hypothesised that the TUG would identify frail patients with COPD. Frailty was assessed in 520 patients diagnosed with COPD and 150 controls using a Comprehensive Geriatric Assessment questionnaire and frailty index (FI) was derived. The TUG was used to assess physical mobility. All participants were assessed for lung function and body composition. A ROC curve was used to identify how well TUG discriminates between frail and non-frail patients with COPD. The patients with COPD and controls were similar in age, sex and BMI but the patients with COPD were more frail, mean ± SD FI 0.16 ± 0.08 than controls 0.05 ± 0.03, P < 0.001. Frail patients with COPD had a greater TUG time (11.55 ± 4.03 s) compared to non-frail patients (9.2 ± 1.6 sec), after controlling for age and lung function (F = 15.94, P < 0.001), and both were greater than the controls (8.3 ± 1.2 sec), P < 0.001. The TUG discriminated between frail and non-frail patients with COPD with an area under the curve of 72 (95% CI: 67-76), and a diagnostic odds ratio of 2.67 (95% CI:1.5-4.6), P < 0.001. The TUG showed the ability to discriminate between frail and non-frail patients with COPD, independent of age and severity of the airflow obstruction. The TUG is a simple, easy and quick measure that could be easily applied in restricted settings to screen for frailty in COPD.
计时起立行走测试（TUG）是一种衡量移动能力的全球指标，并且具有检测虚弱个体的能力。患有慢性阻塞性肺疾病（COPD）的虚弱患者通常未被诊断出来。我们假设 TUG 能够识别患有 COPD 的虚弱患者。使用全面老年评估问卷和虚弱指数（FI）评估了 520 名被诊断患有 COPD 的患者和 150 名对照者的虚弱情况。使用 TUG 评估身体活动能力。所有参与者都进行了肺功能和身体成分评估。使用 ROC 曲线来确定 TUG 区分 COPD 虚弱和非虚弱患者的能力。COPD 患者和对照组在年龄、性别和 BMI 方面相似，但 COPD 患者更虚弱，FI 的平均值 ± 标准差为 0.16 ± 0.08，而对照组为 0.05 ± 0.03，P < 0.001。患有 COPD 的虚弱患者的 TUG 时间（11.55 ± 4.03 秒）比非虚弱患者（9.2 ± 1.6 秒）更长，在控制年龄和肺功能后（F = 15.94，P < 0.001），并且都长于对照组（8.3 ± 1.2 秒），P < 0.001。TUG 能够区分 COPD 虚弱和非虚弱患者，曲线下面积为 72（95%CI：67-76），诊断比值比为 2.67（95%CI：1.5-4.6），P < 0.001。TUG 显示了在独立于年龄和气流阻塞严重程度的情况下区分 COPD 虚弱和非虚弱患者的能力。TUG 是一种简单、易用、快速的测量方法，可以在受限环境中轻松应用，以筛查 COPD 中的虚弱。
