Vrancken Peeters Noëlle J M C, van Til Janine A, Huberts Anouk S, Siesling Sabine, Husson Olga, Koppert Linetta B
Department of Surgical Oncology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Department of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX Amsterdam, The Netherlands.
Cancers (Basel). 2024 May 21;16(11):1952. doi: 10.3390/cancers16111952.
The EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) are commonly used Patient-Reported Outcome Measures (PROMs) for breast cancer. This study assesses and compares the internal responsiveness of the EQ-5D-5L and EORTC QLQ-C30 in Dutch breast cancer patients during the first year post-surgery. Women diagnosed with breast cancer who completed the EQ-5D-5L and EORTC QLQ-C30 pre-operatively (T0), 6 months (T6), and 12 months post-surgery (T12) were included. Mean differences of the EQ-5D-5L and EORTC QLQ-C30 between baseline and 6 months (delta 1) and between baseline and 12 months post-surgery (delta 2) were calculated and compared against the respective minimal clinically important differences (MCIDs) of 0.08 and 5. Internal responsiveness was assessed using effect sizes (ES) and standardized response means (SRM) for both deltas. In total, 333 breast cancer patients were included. Delta 1 and delta 2 for the EQ-5D-5L index and most scales of the EORTC QLQ-C30 were below the MCID. The internal responsiveness for both PROMs was small (ES and SRM < 0.5), with greater internal responsiveness for delta 1 compared to delta 2. The EQ-5D-5L index showed greater internal responsiveness than the EORTC QLQ-C30 Global Quality of Life scale and summary score. These findings are valuable for the interpretation of both PROMs in Dutch breast cancer research and clinical care.
欧洲五维健康量表（EQ-5D-5L）和欧洲癌症研究与治疗组织生活质量核心问卷30项（EORTC QLQ-C30）是乳腺癌中常用的患者报告结局测量指标（PROMs）。本研究评估并比较了荷兰乳腺癌患者术后第一年中EQ-5D-5L和EORTC QLQ-C30的内部反应性。纳入了术前（T0）、术后6个月（T6）和术后12个月（T12）完成EQ-5D-5L和EORTC QLQ-C30的乳腺癌女性患者。计算了EQ-5D-5L和EORTC QLQ-C30在基线与6个月之间（delta 1）以及基线与术后12个月之间（delta 2）的平均差异，并与各自最小临床重要差异（MCIDs）0.08和5进行比较。使用效应量（ES）和标准化反应均值（SRM）对两个delta评估内部反应性。总共纳入了333例乳腺癌患者。EQ-5D-5L指数和EORTC QLQ-C30的大多数量表的delta 1和delta 2均低于MCID。两种PROMs的内部反应性均较小（ES和SRM < 0.5），delta 1的内部反应性比delta 2更大。EQ-5D-5L指数显示出比EORTC QLQ-C30总体生活质量量表和总结得分更大的内部反应性。这些发现对于荷兰乳腺癌研究和临床护理中两种PROMs的解释具有重要价值。
