Department of Medical Psychology and Medical Sociology, University of Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Rehabilitation Clinic Bad Oexen, Bad Oeynhausen, Germany.
Sci Rep. 2021 Mar 4;11(1):5191. doi: 10.1038/s41598-021-84681-0.
Quality of life (QoL) is an important outcome criterion in cancer research and practice. Multiple studies have been performed to test the short-term temporal stability (1 day-2 weeks) of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire EORTC QLQ-C30, but its stability over longer periods of time is largely unknown. The EORTC QLQ-C30 was administered at two time points between 3 and 12 months apart in six samples of cancer patients with varying characteristics (N between 298 and 923). Averaged across the six samples, the coefficients of temporal stability (intra-class correlation coefficients ICC) were between 0.31 and 0.59 for the single scales. The 2-item global health/QoL scale showed a mean coefficient of 0.44. When the stability coefficients were calculated separately for males and females and for younger vs. older patients, no systematic gender or age differences were found in the temporal stability of the QoL scales, though the stability was slightly higher in males (vs. females) and in older subgroups (vs. younger subgroups). It is nearly impossible to predict the course a cancer patients' QoL will take over a several month period. Repeated measurements are necessary to track QoL developments.
生活质量（QoL）是癌症研究和实践中的一个重要结果标准。已经进行了多项研究来测试欧洲癌症研究与治疗组织（EORTC）生活质量问卷 EORTC QLQ-C30 的短期时间稳定性（1 天-2 周），但其在较长时间内的稳定性在很大程度上尚不清楚。EORTC QLQ-C30 在六个具有不同特征的癌症患者样本中，在相隔 3 至 12 个月的两个时间点进行了两次测量（N 介于 298 和 923 之间）。在六个样本的平均值中，单个量表的时间稳定性（组内相关系数 ICC）系数在 0.31 到 0.59 之间。2 项全球健康/生活质量量表的平均系数为 0.44。当稳定性系数分别按男性和女性以及年轻患者与老年患者进行计算时，在生活质量量表的时间稳定性方面没有发现系统的性别或年龄差异，尽管男性（与女性相比）和年龄较大的亚组（与年轻亚组相比）的稳定性略高。几乎不可能预测癌症患者在几个月内的生活质量状况。需要进行重复测量以跟踪生活质量的发展。
