Kallopterolides A-I，一种从西南加勒比海羽流中分离得到的新型 -二萜类化合物。

Kallopterolides A-I, a New Subclass of -Diterpenes Isolated from the Southwestern Caribbean Sea Plume .

机构信息

Department of Chemistry, University of Puerto Rico, 17 Ave. Universidad STE 1701, San Juan, PR 00931, USA.

Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan, PR 00926, USA.

出版信息

Molecules. 2024 May 24;29(11):2493. doi: 10.3390/molecules29112493.

DOI:10.3390/molecules29112493

PMID:38893370

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11173908/

Abstract

Kallopterolides A-I (-), a family of nine diterpenoids possessing either a cleaved pseudopterane or a severed cembrane skeleton, along with several known compounds were isolated from the Caribbean Sea plume . The structures and relative configurations of - were characterized by analysis of HR-MS, IR, UV, and NMR spectroscopic data in addition to computational methods and side-by-side comparisons with published NMR data of related congeners. An investigation was conducted as to the potential of the kallopterolides as plausible in vitro anti-inflammatory, antiprotozoal, and antituberculosis agents.

摘要

从加勒比海羽烟中分离得到了 Kallopterolides A-I(-)，这是一类具有裂解假蒴烷或断裂 cembrane 骨架的九个二萜类化合物，以及几种已知化合物。通过分析高分辨质谱、红外、紫外和核磁共振波谱数据，以及计算方法，并与相关同系物的已发表 NMR 数据进行并排比较，确定了 - 的结构和相对构型。研究了 kallopterolides 作为潜在的体外抗炎、抗原生动物和抗结核药物的可能性。