Reczkowski Jakub, Długosz Maria, Ratajczak Maria, Voelkel Adam, Sandomierski Mariusz
Institute of Chemical Technology and Engineering, Poznan University of Technology, ul. Berdychowo 4, 60-965 Poznań, Poland.
Institute of Building Engineering, Poznan University of Technology, ul. Piotrowo 5, 60-965 Poznań, Poland.
Materials (Basel). 2024 May 21;17(11):2473. doi: 10.3390/ma17112473.
The essence of drug delivery is to use an appropriate carrier that delivers the active substance to the appropriate pathogenic site at a specific time. This study aims to develop a novel drug carrier characterized by the controlled and targeted release of risedronate (RSD). The search for new routes to deliver RSD is important because oral delivery has many disadvantages. The carrier proposed in this work is composed of gelatin, polyphosphates, and zinc. The zinc contained in the carrier is responsible for coordinating the drug. The resulting material releases RSD in a controlled manner. The rate of delivery of the substance to the body depends on the pH of the environment. This study investigated the delivery of RSD in a neutral environment, where the process exhibited a prolonged and consistent release rate. This process has also been studied in an acidic environment, which accelerates the release of the drug. Mixed-environment studies were also conducted. Initially, the drug was released in a neutral environment, and then the conditions rapidly changed to acidic. In this case, the carrier demonstrated high stability and controlled release, adapting the rate of drug release to the prevailing environmental conditions. The presented results indicate the great potential of the new gelatin-based carrier in the delivery of risedronate.
药物递送的本质是使用合适的载体，在特定时间将活性物质递送至合适的致病部位。本研究旨在开发一种以利塞膦酸盐（RSD）的控释和靶向释放为特征的新型药物载体。寻找递送RSD的新途径很重要，因为口服给药有许多缺点。本研究中提出的载体由明胶、多磷酸盐和锌组成。载体中含有的锌负责与药物配位。所得材料以可控方式释放RSD。该物质向体内的递送速率取决于环境的pH值。本研究在中性环境中研究了RSD的递送，该过程呈现出延长且一致的释放速率。该过程也在酸性环境中进行了研究，酸性环境会加速药物释放。还进行了混合环境研究。最初，药物在中性环境中释放，然后条件迅速变为酸性。在这种情况下，载体表现出高稳定性和控释性，使药物释放速率适应主要的环境条件。所呈现的结果表明新型明胶基载体在递送利塞膦酸盐方面具有巨大潜力。
