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CRISPR-based screening pinpoints H2AZ1 as a driver of senescence in human mesenchymal stem cells.

作者信息

Li Ming-Heng, Jiang Xiaoyu, Jing Yaobin, Yan Kaowen, Bi Shi-Jia, Wang Si, Ma Shuai, Liu Guang-Hui, Zhang Weiqi, Sun Shuhui, Qu Jing

机构信息

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Protein Cell. 2025 Apr 18;16(4):296-305. doi: 10.1093/procel/pwae035.

DOI:10.1093/procel/pwae035
PMID:38894586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12082294/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759c/12082294/045fd783c1b1/pwae035_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759c/12082294/ea9047c2eb93/pwae035_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759c/12082294/045fd783c1b1/pwae035_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759c/12082294/ea9047c2eb93/pwae035_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/759c/12082294/045fd783c1b1/pwae035_fig2.jpg

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2
SenoIndex: S100A8/S100A9 as a novel aging biomarker.衰老指数：S100A8/S100A9作为一种新型衰老生物标志物。
Life Med. 2023 Jun 13;2(4):lnad022. doi: 10.1093/lifemedi/lnad022. eCollection 2023 Aug.
3
A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement.肝脏衰老的生物标志物框架：衰老生物标志物联盟共识声明。
Life Med. 2024 Jan 30;3(1):lnae004. doi: 10.1093/lifemedi/lnae004. eCollection 2024 Feb.
4
Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells.迁移小体触发先天性免疫激活并介导衰老信号在人类细胞间的传递。
Life Med. 2023 Dec 8;2(6):lnad050. doi: 10.1093/lifemedi/lnad050. eCollection 2023 Dec.
5
The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA.人类衰老相关的 Sirtuin 途径汇集于胎盘特异性基因 PAPPA 的激活。
Dev Cell. 2024 Apr 22;59(8):991-1009.e12. doi: 10.1016/j.devcel.2024.02.008. Epub 2024 Mar 13.
6
DNA methylation clocks for estimating biological age in Chinese cohorts.用于估算中国队列生物年龄的 DNA 甲基化时钟。
Protein Cell. 2024 Jul 20;15(8):575-593. doi: 10.1093/procel/pwae011.
7
Stress, epigenetics, and aging: Unraveling the intricate crosstalk.压力、表观遗传学与衰老：解析复杂的相互作用
Mol Cell. 2024 Jan 4;84(1):34-54. doi: 10.1016/j.molcel.2023.10.006. Epub 2023 Nov 13.
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Biomarkers of aging.衰老的生物标志物。
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Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging.单细胞 profiling 揭示了 FOXO3 在灵长类骨骼肌衰老中的 geroprotective 作用。
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