Pocock Helen, Rees Nigel, Gunson Imogen, Docherty Mark, Charlton Karl, Jackson Michelle, Scomparin Charlotte, England Ed, Fothergill Rachael
South Central Ambulance Service NHS Foundation Trust, UK.
Warwick Clinical Trials Unit, University of Warwick, UK.
Resusc Plus. 2024 Mar 27;18:100617. doi: 10.1016/j.resplu.2024.100617. eCollection 2024 Jun.
PARAMEDIC2 was a medicines trial comparing adrenaline with placebo in out-of-hospital cardiac arrest (OHCA). At the time, United Kingdom (UK) Emergency Medical Systems (EMS) were inexperienced in delivering such research.
To identify barriers and facilitators to delivery of the PARAMEDIC2 (Adrenaline) trial by five UK NHS EMS.
This qualitative study took a grounded theory approach to thematic analysis of workshop data. Members of the trial teams from each service attended a workshop in November 2018 and discussed their experiences in answer to two prompt questions. Data were coded and themes presented.
Three main themes were identified: and . The study provided an opportunity for recruiting paramedics and research paramedics to demonstrate their . Research paramedics felt it was part of their professional duty to initiate discussions with the patient/family regarding the trial rather than leave this task to the hospital teams as would usually happen. was reflected by prioritising trial training and further development of research paramedics. By these means, research culture was developed. The such as geographical challenges were often addressed with technological solutions and through building relationships with internal teams.
Barriers to trial delivery included infrequent exposure to the condition of interest and lack of continuity in research paramedic roles. Facilitators identified included flexibility of the research protocol, and organisational investment in the development of research paramedics.Participating in PARAMEDIC2 was challenging for the EMS involved, but ultimately strengthened their research culture.
PARAMEDIC2是一项在院外心脏骤停（OHCA）中比较肾上腺素与安慰剂的药物试验。当时，英国（UK）紧急医疗系统（EMS）在开展此类研究方面经验不足。
确定英国国民健康服务体系（NHS）的五个紧急医疗服务机构开展PARAMEDIC2（肾上腺素）试验的障碍和促进因素。
本定性研究采用扎根理论方法对研讨会数据进行主题分析。每个服务机构的试验团队成员于2018年11月参加了一次研讨会，并就两个提示性问题讨论了他们的经验。对数据进行编码并呈现主题。
确定了三个主要主题：以及。该研究为招募护理人员和研究护理人员展示他们的提供了机会。研究护理人员认为，与患者/家属就试验展开讨论是他们的职业职责的一部分，而不是像通常那样将这项任务留给医院团队。通过优先安排试验培训和进一步发展研究护理人员得以体现。通过这些方式，形成了研究文化。诸如地理挑战等通常通过技术解决方案以及与内部团队建立关系来解决。
试验实施的障碍包括对感兴趣的病症接触不频繁以及研究护理人员角色缺乏连续性。确定的促进因素包括研究方案的灵活性以及组织对研究护理人员发展的投入。参与PARAMEDIC2对相关紧急医疗服务机构来说具有挑战性，但最终强化了他们的研究文化。
