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长链非编码 RNA 在炎症性肠病中的作用。

Role of long non-coding RNA in inflammatory bowel disease.

机构信息

Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.

Department of Geriatrics, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.

出版信息

Front Immunol. 2024 Jun 4;15:1406538. doi: 10.3389/fimmu.2024.1406538. eCollection 2024.

DOI:10.3389/fimmu.2024.1406538
PMID:38895124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11183289/
Abstract

Inflammatory bowel disease (IBD) is a group of recurrent chronic inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC). Although IBD has been extensively studied for decades, its cause and pathogenesis remain unclear. Existing research suggests that IBD may be the result of an interaction between genetic factors, environmental factors and the gut microbiome. IBD is closely related to non-coding RNAs (ncRNAs). NcRNAs are composed of microRNA(miRNA), long non-coding RNA(lnc RNA) and circular RNA(circ RNA). Compared with miRNA, the role of lnc RNA in IBD has been little studied. Lnc RNA is an RNA molecule that regulates gene expression and regulates a variety of molecular pathways involved in the pathbiology of IBD. Targeting IBD-associated lnc RNAs may promote personalized treatment of IBD and have therapeutic value for IBD patients. Therefore, this review summarized the effects of lnc RNA on the intestinal epithelial barrier, inflammatory response and immune homeostasis in IBD, and summarized the potential of lnc RNA as a biomarker of IBD and as a predictor of therapeutic response to IBD in the future.

摘要

炎症性肠病（IBD）是一组反复发作的慢性炎症性疾病，包括克罗恩病（CD）和溃疡性结肠炎（UC）。尽管几十年来对 IBD 进行了广泛的研究，但它的病因和发病机制仍不清楚。现有研究表明，IBD 可能是遗传因素、环境因素和肠道微生物组相互作用的结果。IBD 与非编码 RNA（ncRNA）密切相关。ncRNA 由 microRNA（miRNA）、长链非编码 RNA（lncRNA）和环状 RNA（circRNA）组成。与 miRNA 相比，lncRNA 在 IBD 中的作用研究较少。lncRNA 是一种调节基因表达的 RNA 分子，调节涉及 IBD 病理生物学的多种分子途径。针对与 IBD 相关的 lncRNA 可能促进 IBD 的个性化治疗，对 IBD 患者具有治疗价值。因此，本综述总结了 lncRNA 在 IBD 中对肠道上皮屏障、炎症反应和免疫稳态的影响，并总结了 lncRNA 作为 IBD 生物标志物和未来预测 IBD 治疗反应的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/5f854e478010/fimmu-15-1406538-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/66e6f6ae8959/fimmu-15-1406538-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/fc9317c2baf2/fimmu-15-1406538-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/386658ecc4ec/fimmu-15-1406538-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/995f67fa7ecf/fimmu-15-1406538-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/d4c668b16358/fimmu-15-1406538-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/5f854e478010/fimmu-15-1406538-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/66e6f6ae8959/fimmu-15-1406538-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/fc9317c2baf2/fimmu-15-1406538-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/386658ecc4ec/fimmu-15-1406538-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/995f67fa7ecf/fimmu-15-1406538-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/d4c668b16358/fimmu-15-1406538-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b89f/11183289/5f854e478010/fimmu-15-1406538-g006.jpg

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Transcriptomic study reveals lncRNA-mediated downregulation of innate immune and inflammatory response in the SARS-CoV-2 vaccination breakthrough infections.转录组研究揭示了 lncRNA 在 SARS-CoV-2 突破性感染中的固有免疫和炎症反应下调机制。
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