Smirnov V F, Mikerova T M, Gerasimova N P
Med Radiol (Mosk). 1985 May;30(5):61-6.
To determine the area of application of citon, a radiopharmaceutical produced in Hungary, a study was made of its major pharmacokinetic properties with relation to the nature and rate of its release from the blood, selective renal excretion, the time of diffusing from the plasma and the time of passing through the kidneys. A total of 45 patients were examined with the help of a computerized gamma-chamber and renograph in the course of dynamic scintigraphy and renography. Analysing the data obtained on the basis of a chamber model of the indicator behavior, using appropriate processing of the recorded curves one can conclude that the behavior of citon differed little from that of other filtrating agents, such as 99mTc-DTPA.
为确定匈牙利生产的放射性药物西通（citon）的应用范围，对其主要药代动力学特性进行了研究，包括其从血液中释放的性质和速率、选择性肾脏排泄、从血浆扩散的时间以及通过肾脏的时间。在动态闪烁扫描和肾造影过程中，借助计算机化伽马室和肾图仪对45名患者进行了检查。基于示踪剂行为的室模型分析所获得的数据，对记录曲线进行适当处理后可以得出结论，西通的行为与其他滤过剂（如99mTc - DTPA）的行为差异不大。
