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类蝰蛇蛋白在植物中干扰RNA病毒。

Viperin-like proteins interfere with RNA viruses in plants.

作者信息

Kamel Radwa, Aman Rashid, Mahfouz Magdy M

机构信息

Laboratory for Genome Engineering and Synthetic Biology, Division of Biological Sciences, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

出版信息

Front Plant Sci. 2024 Jun 4;15:1385169. doi: 10.3389/fpls.2024.1385169. eCollection 2024.

DOI:10.3389/fpls.2024.1385169
PMID:38895613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11185175/
Abstract

Plant viruses cause substantial losses in crop yield and quality; therefore, devising new, robust strategies to counter viral infections has important implications for agriculture. Virus inhibitory protein endoplasmic reticulum-associated interferon-inducible (Viperin) proteins are conserved antiviral proteins. Here, we identified a set of Viperin and Viperin-like proteins from multiple species and tested whether they could interfere with RNA viruses . Our data from transient and stable overexpression of these proteins in reveal varying levels of interference against the RNA viruses tobacco mosaic virus (TMV), turnip mosaic virus (TuMV), and potato virus x (PVX). Harnessing the potential of these proteins represents a novel avenue in plant antiviral approaches, offering a broader and more effective spectrum for application in plant biotechnology and agriculture. Identifying these proteins opens new avenues for engineering a broad range of resistance to protect crop plants against viral pathogens.

摘要

植物病毒会导致作物产量和品质大幅下降；因此，制定新的、强有力的策略来对抗病毒感染对农业具有重要意义。病毒抑制蛋白内质网相关干扰素诱导蛋白（Viperin）是保守的抗病毒蛋白。在这里，我们从多个物种中鉴定出一组Viperin和Viperin样蛋白，并测试了它们是否能干扰RNA病毒。我们在[具体实验对象]中对这些蛋白进行瞬时和稳定过表达的数据显示，它们对RNA病毒烟草花叶病毒（TMV）、芜菁花叶病毒（TuMV）和马铃薯X病毒（PVX）的干扰程度各不相同。利用这些蛋白的潜力代表了植物抗病毒方法中的一条新途径，为植物生物技术和农业应用提供了更广泛、更有效的范围。鉴定这些蛋白为设计广泛的抗性以保护作物免受病毒病原体侵害开辟了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/dea52e4a686a/fpls-15-1385169-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/9fef88987a0c/fpls-15-1385169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/228015b451ec/fpls-15-1385169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/67f448414826/fpls-15-1385169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/dea52e4a686a/fpls-15-1385169-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/9fef88987a0c/fpls-15-1385169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/228015b451ec/fpls-15-1385169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/67f448414826/fpls-15-1385169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1788/11185175/dea52e4a686a/fpls-15-1385169-g004.jpg

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本文引用的文献

1
Plant Viruses of Agricultural Importance: Current and Future Perspectives of Virus Disease Management Strategies.具有农业重要性的植物病毒：病毒病害管理策略的现状与未来展望
Phytopathology. 2023 Feb;113(2):117-141. doi: 10.1094/PHYTO-05-22-0167-RVW. Epub 2023 Feb 27.
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Systematic and quantitative view of the antiviral arsenal of prokaryotes.原核生物抗病毒武器库的系统和定量分析。
Nat Commun. 2022 May 10;13(1):2561. doi: 10.1038/s41467-022-30269-9.
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Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2021).
病毒分类学和国际病毒分类与命名法规的变更获国际病毒学分类委员会批准（2021 年）。
Arch Virol. 2021 Sep;166(9):2633-2648. doi: 10.1007/s00705-021-05156-1.
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Novel and emerging biotechnological crop protection approaches.新型和新兴的生物技术作物保护方法。
Plant Biotechnol J. 2021 Aug;19(8):1495-1510. doi: 10.1111/pbi.13605. Epub 2021 May 18.
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RNA-Based Technologies for Engineering Plant Virus Resistance.用于构建植物病毒抗性的基于RNA的技术
Plants (Basel). 2021 Jan 2;10(1):82. doi: 10.3390/plants10010082.
6
Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity.通过CRISPR/Cas系统介导的适应性免疫控制植物病毒
Front Microbiol. 2020 Oct 26;11:593700. doi: 10.3389/fmicb.2020.593700. eCollection 2020.
7
Prokaryotic viperins produce diverse antiviral molecules.原核 viperin 产生多种抗病毒分子。
Nature. 2021 Jan;589(7840):120-124. doi: 10.1038/s41586-020-2762-2. Epub 2020 Sep 16.
8
Viperin Reveals Its True Function.Viperin 揭示其真正功能。
Annu Rev Virol. 2020 Sep 29;7(1):421-446. doi: 10.1146/annurev-virology-011720-095930. Epub 2020 Jun 30.
9
CRISPR-Cas13d mediates robust RNA virus interference in plants.CRISPR-Cas13d 介导植物中强大的 RNA 病毒干扰。
Genome Biol. 2019 Dec 2;20(1):263. doi: 10.1186/s13059-019-1881-2.
10
Global Dimensions of Plant Virus Diseases: Current Status and Future Perspectives.植物病毒病的全球维度：现状与未来展望。
Annu Rev Virol. 2019 Sep 29;6(1):387-409. doi: 10.1146/annurev-virology-092818-015606. Epub 2019 Jul 5.