Ihesiulor Chikezie Grand, Alzahrani Khaled, Rhadhakrishnan Hema
Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M139PL, United Kingdom.
Department of Ophthalmology, King Fahad Armed Forces Hospital, Jeddah 23311, Saudi Arabia.
Int J Ophthalmol. 2024 Jun 18;17(6):1144-1155. doi: 10.18240/ijo.2024.06.21. eCollection 2024.
Various studies have suggested several environmental, pharmacological, medical, and optical interventions and some are in use but their efficacy in myopia control may be transient, and the cellular, molecular, and biochemical mechanisms involved unclear. Daylight exposure is currently regarded as an effective and enduring strategy in the control of myopia development and progression. However, the mechanism behind the effect of outdoor exposure and its association with genetic predisposition and other relatively more significant environmental factors on myopia is still a conundrum. This review focuses on survey-based and intervention-based studies carried out to propose a mechanism that accounts for myopia development and important for its control.
多项研究提出了几种环境、药物、医学和光学干预措施，其中一些正在使用，但它们在控制近视方面的效果可能是短暂的，所涉及的细胞、分子和生化机制尚不清楚。目前，日光暴露被认为是控制近视发展和进展的一种有效且持久的策略。然而，户外暴露产生这种效果的背后机制，以及它与遗传易感性和其他相对更重要的环境因素对近视的关联，仍然是一个谜。本综述重点关注基于调查和基于干预的研究，旨在提出一种解释近视发展并对其控制至关重要的机制。
